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Molecules 2007, 12(7), 1455-1470; doi:10.3390/12071455

The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice

1
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Xuzhou Normal University, Xuzhou 221116, Jiangsu Province, P. R. China
2
School of Environment Science and Spatial Informatics, China University of Mining and Technology, Xuzhou 221008, Jiangsu Province, P. R. China
*
Author to whom correspondence should be addressed.
Received: 30 May 2007 / Revised: 3 July 2007 / Accepted: 13 July 2007 / Published: 19 July 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Abstract

The purpose of this study was to explore the neuroprotective effects of daidzein on the apoptotic pathway in the hippocampus and cortex of D-galactose treated mice. For this purpose we have examined the expression of bcl-2 mRNA, bax mRNA and caspase-3 in the hippocampus and cortex of D-galactose-treated mice after fed with 10 or 5 mg/kg of daidzein. The results of in situ hybridization experiments indicate that daidzein could help increase the transcriptions of bcl-2 and decrease the transcriptions of bax in those brain regions of D-galactose-treated mice. Furthermore, immunohistochemical studies showed that daidzein could reduce the expression of caspase-3 in both brain regions. These results suggest that daidzein in soybean can inhibit the D-gal induced apoptosis via Bcl-2/Bax apoptotic pathway and be a potential medical candidate for neurodegeneration therapy.
Keywords: Daidzein; apoptosis; caspase 3; bcl-2; bax Daidzein; apoptosis; caspase 3; bcl-2; bax
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Mao, Z.; Zheng, Y.-L.; Zhang, Y.-Q.; Han, B.-P.; Zhu, X.-W.; Chang, Q.; Hu, X.-B. The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice. Molecules 2007, 12, 1455-1470.

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