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The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Xuzhou Normal University, Xuzhou 221116, Jiangsu Province, P. R. China
School of Environment Science and Spatial Informatics, China University of Mining and Technology, Xuzhou 221008, Jiangsu Province, P. R. China
* Author to whom correspondence should be addressed.
Received: 30 May 2007; in revised form: 3 July 2007 / Accepted: 13 July 2007 / Published: 19 July 2007
Abstract: The purpose of this study was to explore the neuroprotective effects of daidzein on the apoptotic pathway in the hippocampus and cortex of D-galactose treated mice. For this purpose we have examined the expression of bcl-2 mRNA, bax mRNA and caspase-3 in the hippocampus and cortex of D-galactose-treated mice after fed with 10 or 5 mg/kg of daidzein. The results of in situ hybridization experiments indicate that daidzein could help increase the transcriptions of bcl-2 and decrease the transcriptions of bax in those brain regions of D-galactose-treated mice. Furthermore, immunohistochemical studies showed that daidzein could reduce the expression of caspase-3 in both brain regions. These results suggest that daidzein in soybean can inhibit the D-gal induced apoptosis via Bcl-2/Bax apoptotic pathway and be a potential medical candidate for neurodegeneration therapy.
Keywords: Daidzein; apoptosis; caspase 3; bcl-2; bax
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Mao, Z.; Zheng, Y.-L.; Zhang, Y.-Q.; Han, B.-P.; Zhu, X.-W.; Chang, Q.; Hu, X.-B. The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice. Molecules 2007, 12, 1455-1470.
Mao Z, Zheng Y-L, Zhang Y-Q, Han B-P, Zhu X-W, Chang Q, Hu X-B. The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice. Molecules. 2007; 12(7):1455-1470.
Mao, Zhen; Zheng, Yuan-lin; Zhang, Yan-qiu; Han, Bao-ping; Zhu, Xiao-wan; Chang, Qing; Hu, Xiang-bin. 2007. "The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice." Molecules 12, no. 7: 1455-1470.