Abstract: The purpose of this study was to explore the neuroprotective effects of daidzein on the apoptotic pathway in the hippocampus and cortex of D-galactose treated mice. For this purpose we have examined the expression of bcl-2 mRNA, bax mRNA and caspase-3 in the hippocampus and cortex of D-galactose-treated mice after fed with 10 or 5 mg/kg of daidzein. The results of in situ hybridization experiments indicate that daidzein could help increase the transcriptions of bcl-2 and decrease the transcriptions of bax in those brain regions of D-galactose-treated mice. Furthermore, immunohistochemical studies showed that daidzein could reduce the expression of caspase-3 in both brain regions. These results suggest that daidzein in soybean can inhibit the D-gal induced apoptosis via Bcl-2/Bax apoptotic pathway and be a potential medical candidate for neurodegeneration therapy.
Keywords: Daidzein; apoptosis; caspase 3; bcl-2; bax
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Mao, Z.; Zheng, Y.-L.; Zhang, Y.-Q.; Han, B.-P.; Zhu, X.-W.; Chang, Q.; Hu, X.-B. The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice. Molecules 2007, 12, 1455-1470.
Mao Z, Zheng Y-L, Zhang Y-Q, Han B-P, Zhu X-W, Chang Q, Hu X-B. The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice. Molecules. 2007; 12(7):1455-1470.
Mao, Zhen; Zheng, Yuan-lin; Zhang, Yan-qiu; Han, Bao-ping; Zhu, Xiao-wan; Chang, Qing; Hu, Xiang-bin. 2007. "The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice." Molecules 12, no. 7: 1455-1470.