Molecules 2007, 12(7), 1455-1470; doi:10.3390/12071455
Article

The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice

Zhen Mao 1 email, Yuan-lin Zheng 1,* email, Yan-qiu Zhang 1 , Bao-ping Han 1 , Xiao-wan Zhu 1 , Qing Chang 1  and Xiang-bin Hu 1
1 Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Xuzhou Normal University, Xuzhou 221116, Jiangsu Province, P. R. China 2 School of Environment Science and Spatial Informatics, China University of Mining and Technology, Xuzhou 221008, Jiangsu Province, P. R. China
* Author to whom correspondence should be addressed.
Received: 30 May 2007; in revised form: 3 July 2007 / Accepted: 13 July 2007 / Published: 19 July 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Abstract: The purpose of this study was to explore the neuroprotective effects of daidzein on the apoptotic pathway in the hippocampus and cortex of D-galactose treated mice. For this purpose we have examined the expression of bcl-2 mRNA, bax mRNA and caspase-3 in the hippocampus and cortex of D-galactose-treated mice after fed with 10 or 5 mg/kg of daidzein. The results of in situ hybridization experiments indicate that daidzein could help increase the transcriptions of bcl-2 and decrease the transcriptions of bax in those brain regions of D-galactose-treated mice. Furthermore, immunohistochemical studies showed that daidzein could reduce the expression of caspase-3 in both brain regions. These results suggest that daidzein in soybean can inhibit the D-gal induced apoptosis via Bcl-2/Bax apoptotic pathway and be a potential medical candidate for neurodegeneration therapy.
Keywords: Daidzein; apoptosis; caspase 3; bcl-2; bax

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MDPI and ACS Style

Mao, Z.; Zheng, Y.-L.; Zhang, Y.-Q.; Han, B.-P.; Zhu, X.-W.; Chang, Q.; Hu, X.-B. The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice. Molecules 2007, 12, 1455-1470.

AMA Style

Mao Z, Zheng Y-L, Zhang Y-Q, Han B-P, Zhu X-W, Chang Q, Hu X-B. The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice. Molecules. 2007; 12(7):1455-1470.

Chicago/Turabian Style

Mao, Zhen; Zheng, Yuan-lin; Zhang, Yan-qiu; Han, Bao-ping; Zhu, Xiao-wan; Chang, Qing; Hu, Xiang-bin. 2007. "The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice." Molecules 12, no. 7: 1455-1470.

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