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Molecules 2007, 12(7), 1447-1454; doi:10.3390/12071447
Article

Leufolins A and B, Potent Butyrylcholinesterase-inhibiting Flavonoid Glucosides from Leucas urticifolia

1, 1, 2, 1,* , 3, 3, 3 and 3
1 International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan 2 Medicinal Botanic Centre, PCSIR Labs. Complex Peshawar, Peshawar, N.W.F.P, Pakistan 3 Pharmaceutical Research Centre, PCSIR Labs. Complex, Karachi-75280, Pakistan
* Author to whom correspondence should be addressed.
Received: 2 July 2007 / Revised: 12 July 2007 / Accepted: 12 July 2007 / Published: 19 July 2007
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Abstract

New flavonoidal glucosides leufolins A (1) and B (2), have been isolated from the ethyl acetate soluble fraction of the whole plants of Leucas urticifolia. Their structures were elucidated on the basis of extensive analysis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Both of these compounds exhiited significant inhibitory potential against the enzyme butyrylcholinesterase.
Keywords: Leucas urticifolia; Lamiaceae; Leufolin A; Leufolin B; Butyrylcholinesterase; Leucas urticifolia; Lamiaceae; Leufolin A; Leufolin B; Butyrylcholinesterase; Inhibitory activity Leucas urticifolia; Lamiaceae; Leufolin A; Leufolin B; Butyrylcholinesterase; Leucas urticifolia; Lamiaceae; Leufolin A; Leufolin B; Butyrylcholinesterase; Inhibitory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Noor, A.-T.; Fatima, I.; Ahmad, I.; Malik, A.; Afza, N.; Iqbal, L.; Latif, M.; Khan, S.B. Leufolins A and B, Potent Butyrylcholinesterase-inhibiting Flavonoid Glucosides from Leucas urticifolia. Molecules 2007, 12, 1447-1454.

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