Molecules 2007, 12(7), 1471-1481; doi:10.3390/12071471
Article

Unusual Reactivity Patterns of 1,3,6,8-Tetraazatricyclo-[4.4.1.13,8]-dodecane (TATD) Towards Some Reducing Agents: Synthesis of TMEDA

Received: 10 May 2007; in revised form: 29 June 2007 / Accepted: 29 June 2007 / Published: 19 July 2007
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: N,N,N ́,N ́-Tetramethylethylenediamine (TMEDA) can be synthesized by simple reduction of 1,3,6,8-tetraazatricyclo-[4.4.1.1.3,8]dodecane (TATD), an aminal cage type amine, with formic acid. The aminal can be converted to TMEDA in high yield very easily and in a very short time. We comment on the scope and limitations of the reduction of thisaminal and propose a possible reaction mechanism.
Keywords: Aminals; TMEDA; aminal reduction; Leuckart-Wallach reaction
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MDPI and ACS Style

Rivera, A.; Rios-Motta, J. Unusual Reactivity Patterns of 1,3,6,8-Tetraazatricyclo-[4.4.1.13,8]-dodecane (TATD) Towards Some Reducing Agents: Synthesis of TMEDA. Molecules 2007, 12, 1471-1481.

AMA Style

Rivera A, Rios-Motta J. Unusual Reactivity Patterns of 1,3,6,8-Tetraazatricyclo-[4.4.1.13,8]-dodecane (TATD) Towards Some Reducing Agents: Synthesis of TMEDA. Molecules. 2007; 12(7):1471-1481.

Chicago/Turabian Style

Rivera, Augusto; Rios-Motta, Jaime. 2007. "Unusual Reactivity Patterns of 1,3,6,8-Tetraazatricyclo-[4.4.1.13,8]-dodecane (TATD) Towards Some Reducing Agents: Synthesis of TMEDA." Molecules 12, no. 7: 1471-1481.

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