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• Simić, A
• Manojlović, D
• Šegan, D
• Todorović, M
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• Simić, A
• Manojlović, D
• Šegan, D
• Todorović, M
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• Simić, A
• Manojlović, D
• Šegan, D
• Todorović, M

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Molecules 2007, 12(10), 2327-2340; doi:10.3390/12102327

Article

Electrochemical Behavior and Antioxidant and Prooxidant Activity of Natural Phenolics

Aleksandra Simić, Dragan Manojlović* , Dejan Šegan and Marija Todorović

Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia

* Author to whom correspondence should be addressed.

Received: 15 June 2007; in revised form: 4 October 2007 / Accepted: 4 October 2007 / Published: 24 October 2007

(This article belongs to the Special Issue Phenolics and Polyphenolics)

Download PDF Full-Text [138 KB, uploaded 2 October 2008 11:53 CEST]

Abstract: We have investigated the electrochemical oxidation of a number natural phenolics (salicylic acid, m-hydroxybenzoic acid, p-hydroxybenzoic acid, protocatechuic acid, o-coumaric acid, m-coumaric acid, p-coumaric acid, caffeic acid, quercetin and rutin) using cyclic voltammetry. The antioxidant properties of these compounds were also studied. A structural analysis of the tested phenolics suggests that multiple OH substitution and conjugation are important determinants of the free radical scavenging activity and electrochemical behavior. Compounds with low oxidation potentials (Epa lower than 0.45) showed antioxidant activity, whereas compounds with high Epa values (>0.45) act as prooxidants.

Keywords: phenolics; cyclic voltammetry; antioxidant activity; prooxidant activity

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