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Molecules 2006, 11(11), 929-939; doi:10.3390/11110929

Reactivity of 4-tert-Butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with Hydrazines

, * , ,  and
Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Campus Miguel de Unamuno, 37007 Salamanca, Spain
* Author to whom correspondence should be addressed.
Received: 2 November 2006 / Revised: 29 November 2006 / Accepted: 29 November 2006 / Published: 30 November 2006
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The reactivity of 6-(nitrophenyl or trimethoxyphenyl)-4-tert-butyldimethyl- siloxy-1,2,3,6-tetrahydropyridine derivatives with hydrazines under acid conditions is described. The structure of the products isolated − hydrazones, pyrazolines or pyridazinones − depended on the conditions used. In addition, a systematic study of the reaction outcomes was carried out by introducing variations on the substituents of the tetrahydropyridine ring.
Keywords: Siloxy-1; 2; 3; 6-tetrahydropyridines; hydrazones; pyrazolines; pyridazinones. Siloxy-1; 2; 3; 6-tetrahydropyridines; hydrazones; pyrazolines; pyridazinones.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figueroa, J.; Caballero, E.; Puebla, P.; Tomé, F.; Medarde, M. Reactivity of 4-tert-Butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with Hydrazines. Molecules 2006, 11, 929-939.

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