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Preparation of Benzalkonium Salts Differing in the Length of a Side Alkyl Chain
Center of Advanced Studies, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
Department of Chemistry, Faculty of Sciences, J.E. Purkinje University, Usti nad Labem, Czech Republic
Vakos XT, Prague, Czech Republic
Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
* Author to whom correspondence should be addressed.
Received: 3 September 2007; in revised form: 3 October 2007 / Accepted: 4 October 2007 / Published: 24 October 2007
Abstract: Benzalkonium salts are widely used as disinfectants, biocides and detergents,among a variety of other applications. The cationic surface-activity of these saltsdetermines their potential to act as a biocide on both target and non-target organisms. Inthis study, a quick synthesis of a complete set of the benzalkonium salts differing in thelength of an alkylating chain (from C2 to C20) is described. Moreover, their 1H-NMR, HPLC-MS, TLC and HPLC analysis were recorded.
Keywords: Benzalkonium salt; detergent; surfactant; biocide; HPLC; TLC
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Kuca, K.; Marek, J.; Stodulka, P.; Musilek, K.; Hanusova, P.; Hrabinova, M.; Jun, D. Preparation of Benzalkonium Salts Differing in the Length of a Side Alkyl Chain. Molecules 2007, 12, 2341-2347.
Kuca K, Marek J, Stodulka P, Musilek K, Hanusova P, Hrabinova M, Jun D. Preparation of Benzalkonium Salts Differing in the Length of a Side Alkyl Chain. Molecules. 2007; 12(10):2341-2347.
Kuca, Kamil; Marek, Jan; Stodulka, Petr; Musilek, Kamil; Hanusova, Petra; Hrabinova, Martina; Jun, Daniel. 2007. "Preparation of Benzalkonium Salts Differing in the Length of a Side Alkyl Chain." Molecules 12, no. 10: 2341-2347.