**Acknowledgments**

Supported in part by grants from Ministerio de Ciencia e Innovacion and Instituto de Salud Carlos III (ISCIII) BIO2009/09295, SAF2012-40003, PI10/01691, PI10/02983, RD12/0036/0068, CP07/00215, FEDER funding, FP7 Marie Curie Program PIOF-GA-2012-330598 LincMHeM, funds from the "UTE project CIMA" and by the project RNAREG [CSD2009-00080], funded by the Ministry of Science and Innovation under the programme CONSOLIDER INGENIO 2010.
