*Luciferase Reporter Assays*

Luciferase reporter assays were performed using the Promega Luciferase Assay System (Promega, Mannheim, Germany). After aspirating the medium, cells were washed with PBS and lysed in 100 µL 1.2× reporter lysis buffer. In a 96-well plate, 10 µL of the respective cell lysate were mixed with 10 µL of luciferase substrate. Chemiluminescence was measured immediately in a Safire2™ micro-plate reader (Tecan, Crailshaim, Germany).
