Reprint

Viruses and Nuclear Egress

Edited by
October 2022
182 pages
  • ISBN978-3-0365-5696-3 (Hardback)
  • ISBN978-3-0365-5695-6 (PDF)

This is a Reprint of the Special Issue Viruses and Nuclear Egress that was published in

Biology & Life Sciences
Medicine & Pharmacology
Public Health & Healthcare
Summary

This Special Issue of Viruses focuses on the topic of viruses and nuclear egress. Nuclear egress is a fascinating process by which herpesvirus nucleocapsids make their way from the nuclear interior to the cytoplasm. As nuclear egress and the viral proteins that orchestrate it differ from host processes and proteins in important ways, there is interest in targeting antiviral therapies to disrupt this process. Indeed, the recently approved drug maribavir acts in large part by inhibiting a step of nuclear egress. The Special Issue includes five reviews—three on nuclear egress of two alphaherpesviruses, herpes simplex virus and pseudorabies virus; one on a betaherpevirus, human cytomegalovirus; and one on a gammaherpesvirus, Epstein–Barr virus—and five research papers—two on alphaherpesviruses and three on human cytomegalovirus.

Format
  • Hardback
License and Copyright
© 2022 by the authors; CC BY-NC-ND license
Keywords
human cytomegalovirus; core nuclear egress complex; ORF-UL50 deletion; pUL50 phosphosite mutants; phenotypical changes; differential functional relevance; Epstein–Barr virus; BGLF4 kinase; nuclear egress; BFRF1; nuclear envelope modulation; herpesviruses; nuclear egress; primary envelopment; de-envelopment; herpesvirus; pseudorabies virus; PrV; nuclear egress; vesicle-associated membrane protein associated protein; VAPA; VAPB; CRISPR/Cas9 genome editing; enveloped virus budding; nuclear egress; ESCRT; membrane scission; HSV1; pUL34; pUL31; nuclear egress; NEC; targeting integral membrane proteins; TA membrane proteins; inner nuclear membrane (INM); nuclear import; importins; n/a; CMV; herpesviruses; peptide therapy; tegument; nuclear egress; de-envelopment; phosphorylation; nuclear envelopment complex; membrane fusion; hemi-fusion; human cytomegalovirus; nuclear egress; virus assembly; virus–cell interactions; capsid migration; human cytomegalovirus; UL53; UL50; myosin Va; major capsid protein; mass spectrometry; virus genetics; complementing cells; null mutants

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