Reprint
Biomarkers of Environmental Toxicants
Edited by
October 2020
292 pages
- ISBN978-3-03936-736-8 (Hardback)
- ISBN978-3-03936-737-5 (PDF)
This book is a reprint of the Special Issue Biomarkers of Environmental Toxicants that was published in
Biology & Life Sciences
Chemistry & Materials Science
Environmental & Earth Sciences
Public Health & Healthcare
Summary
Biomarkers of environmental toxicants are measures of exposures, some of which can serve to assess disease risk and inter-individual susceptibilities. Metabolites, protein and DNA adducts also serve to elucidate the mechanisms of the bioactivation and detoxication of reactive toxicant intermediates. Some environmental chemicals act as modulators of gene and protein activity, and induce the dysbiosis of the microbiome, which impacts the metabolome and overall health. In this Special Issue on “Biomarkers of Environmental Toxicants”, review articles and original research studies are featured, covering the latest bioanalytical, biochemical and mass spectrometry-based technologies, to monitor exposures through targeted and non-targeted methods, and mechanistic studies that examine the biological effects of environmental toxicants in cells and humans. Diverse topics, such as exposome, microbiome, DNA/protein adducts and t-RNA modifications, as well as important environment toxicants, including heavy metals, benzene, phthalates, aldehydes, glycidol, tobacco smoke and aristolochic acids, are covered. Novel analytical methods, such as protein adductomics, DNA adduct analysis in formalin-fixed paraffin-embedded tissues, site-specific mutagenesis assay and accelerator mass spectrometry, are also included. This collection provides a valuable update of the most recent biochemical and analytical tools that employ biomarkers in toxicology research, biomarker discovery, and exposure and risk assessment in population-based studies.
Format
- Hardback
License
© 2020 by the authors; CC BY-NC-ND license
Keywords
manganese; lead; cadmium; arsenic; hair; children; environment; carcinogen; DNA adducts; biomonitoring; formalin-fixed paraffin-embedded tissues; biomarker; mass spectrometry; human biomonitoring; urine; non-occupational exposure; S-phenyl-mercapturic acid; HPLC-MS/MS; glycidol; Hb adduct; N-(2.3-dihydroxypropyl)valine; in vivo; cancer risk; UPLC/MS/MS; aristolochic acids; food contamination; environmental pollution; root uptake; aristolochic acid nephropathy; Balkan endemic nephropathy; chronic kidney disease; DNA adducts; tobacco smoke; human carcinogen; biomarkers; cancer risk; mass spectrometry; epitranscriptomics; tRNA modifications; stress response mechanisms; codon-biased translation; phthalate; DEHP; biomonitoring; human exposure; toxicity; reproductive; accelerator mass spectrometry; cavity ring down spectrophotometry; radiocarbon; naphthalene; benzo[a]pyrene; cell turnover; triclocarban; metastasis; DNA adducts; biomarkers; haemoglobin; albumin; mass spectrometry; biomarkers; protein adducts; aldehydes; genotoxicity; cancer; diseases; oxidative stress; exposure biomarkers; high-resolution mass spectrometry; data-dependent profiling; derivatization; biological fluids; isotope labeling; DNA lesion; DNA damage; shuttle vector technique; replication block; mutagenicity; mutational spectrum; mutational signature; DNA repair; DNA adduct bypass; site-specific mutagenesis; chemical exposome; biomonitoring; environmental monitoring; mass spectrometry; disease; bioinformatics; gut microbiome; environment; chemical toxicity; n/a