Reprint

Pharmaceutical Crystals

Edited by
April 2020
148 pages
  • ISBN978-3-03928-712-3 (Paperback)
  • ISBN978-3-03928-713-0 (PDF)

This book is a reprint of the Special Issue Pharmaceutical Crystals that was published in

Chemistry & Materials Science
Engineering
Environmental & Earth Sciences
Summary
The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. This book entitled “Pharmaceutical Crystals" focuses on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts, and hydrates, and polymorph crystals are reported. Such crystal structures were investigated in the latest studies that combined morphology, spectroscopic, theoretical calculation, and thermal analysis with crystallographic study. This book highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure–property study of pharmaceutical crystals. The Guest Editors of this book hope the readers enjoy a wide variety of recent studies on Pharmaceutical Crystals.
Format
  • Paperback
License
© 2020 by the authors; CC BY-NC-ND license
Keywords
pharmaceutical cocrystal; melting diagram; liquid assisted grinding; adefovir dipivoxil; dicarboxylic acid; Crystal structure; Imidazole; Benzodioxole; Semicarbazone; DFT; famoxadone; solvent-mediated polymorphic transformation; hydrogen-bond-acceptance ability; crystal structure analysis; structure determination from powder diffraction data; salt optimization; hydrate; ondansetron; hygroscopicity; dehydration; physicochemical properties; cocrystal; solution crystallization; Raman spectroscopy; on-line monitoring; cocrystal formation; cocrystal; famotidine; malonic acid; crystal structure; solubility; hepatitis B; HBV; pharmaceutical crystals; 3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one; 1H-indole; pyrimidin-4(3H)-one; hydrogen bond; Hirshfeld surface analysis; molecular docking study; Nitrofurantoin–4-dimethylaminopyridine (NF-DMAP) salt; DFT study; HOMO-LUMO; reactivity descriptors; hydrogen bonding; carbamazepine; photostability; polymorphs; cocrystal; succinic acid; saccharin; ticagrelor; crystal structure; crystal habit; solubility; dissolution; n/a