The Effect of Lycium Barbarum Polysaccharide on Alcohol-Induced Oxidative Stress in Rats
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemical components and structural analysis
2.2. Effect of LBP on body weight (BW) in experiment rats
2.3. Effects of LBP on liver damage in experiment rats
2.4. Effects of LBP on serum lipid level in experiment rats
2.5. Effects of LBP on antioxidant levels and lipid peroxidation levels in rat liver
2.6. Histopathological analysis
3. Experimental
3.1. Materials
3.2. Extraction of polysaccharides
3.3. Preparation of Lyceum barbarum Polysaccharides
3.4. Infrared spectral analysis
3.5. Animals
3.6. Determinations
3.6.1. Measurement of ALT and AST in serum
3.6.2. Determination of lipid levels in serum
3.6.3. Oxidative Stress parameters in rat livers
3.7. Histopathological studies
3.8. Statistical analyses
4. Conclusions
Acknowledgments
References
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Sample Availability: Samples of the compounds are available from the authors. |
Control group | Ethanol group | Ethanol+LBP group | |
---|---|---|---|
Initial body weight (g) | 209.3 ± 4.1 | 209.5 ± 5.8 | 211.3 ± 5.4 |
Final body weight (g) | 237.5 ± 7.7 | 236.3 ± 5.9 | 239.8 ± 6.9 |
MDA (nmol/mg protein) | SOD (U/mg protein) | CAT (U/mg protein) | GPx (U/mg protein) | GSH (μg/mg protein) | |
---|---|---|---|---|---|
Control group | 7.27 ± 0.76 | 12.53 ± 4.47 | 19.88 ± 3.79 | 4.03 ± 0.87 | 7.49 ± 0.89 |
Ethanol group | 10.19 ± 1.36 * | 6.98 ± 2.85 * | 12.79 ± 3.17* | 1.46 ± 0.58 * | 5.10 ± 0.64 * |
Ethanol+LBP group | 7.47 ± 0.90 ** | 12.07 ± 4.15 ** | 17.06 ± 3.73 ** | 3.50 ± 0.70 ** | 6.57 ± 0.54 ** |
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Cheng, D.; Kong, H. The Effect of Lycium Barbarum Polysaccharide on Alcohol-Induced Oxidative Stress in Rats. Molecules 2011, 16, 2542-2550. https://doi.org/10.3390/molecules16032542
Cheng D, Kong H. The Effect of Lycium Barbarum Polysaccharide on Alcohol-Induced Oxidative Stress in Rats. Molecules. 2011; 16(3):2542-2550. https://doi.org/10.3390/molecules16032542
Chicago/Turabian StyleCheng, Daye, and Hong Kong. 2011. "The Effect of Lycium Barbarum Polysaccharide on Alcohol-Induced Oxidative Stress in Rats" Molecules 16, no. 3: 2542-2550. https://doi.org/10.3390/molecules16032542