Chromatin Proteomics

Dear Colleagues,

Since the identification of histones, as the principal component of the chromatin, several other classes of proteins have been identified. High Mobility Group (HMG) proteins, soon identified after histones, were followed by chromatin modifiers, epigenetic readers, and others. The complexity in the chromatin proteomic composition is increased by the high number and type of post-translational modifications, that have been discovered in the last years, that affect the structure and the function of both the histone and non-histone component of the chromatin. Many of these post-translational modifications (PTMs) are still under investigation and their function is still unclear.

Future challenges of chromatin proteomics will be to identify new PTMs and chromatin factors associated with them and to develop new technologies to dissect the genome architecture and the higher-order chromosomal structures. Studies on the Long Non-coding RNAs (lncRNAs) component of chromatin will shed light on lncRNAs involvement in chromatin remodeling and their interaction with the chromatin protein component. Understanding the critical role of chromatin composition and its function in the regulation of gene expression, in time and space, during development is still an big challenge.

This Special Issue on “Chromatin proteomics” will focus on proteomics studies in the field of chromatin composition, structure, and function. Special interest will be dedicated to advanced methods based on the combination of chromatin fractionation combined to quantitative proteomic analysis. The potential applications in the diagnosis and prognosis of human diseases of epigenetic studies will be addressed.

Prof. Dr. Guidalberto Manfioletti
Guest Editor

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