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Progress of Biocompatible and Biodegradable Polymers in Biomedicine and Environment

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A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 5156

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Special Issue Editors

Dr. Sajjad Haider

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Guest Editor

Department of Chemical Engineering, College of Engineering, King Saud University, PO-BOX 800, Riyadh 11421, Saudi Arabia
Interests: development of biopolymer composites; metal oxides/polymer composite; polymer hydrogels; and electrospun nanofibers for biomedical and water treatment applications

Dr. Adnan Haider

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Guest Editor

Department of Biological Sciences, National University of Medical Sciences, Punjab, Rawalpindi, Pakistan
Interests: development of electrospun nanofibers; biopolymer composites; polymer hydrogels to develop scaffolds for tissue regeneration; drug delivery; water treatment applications

Dr. Ainara Saralegi

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Guest Editor

LSRE - Laboratory of Separation and Reaction Engineering, University of the Basque Country (UPV/EHU), 01006 Leioa, Spain
Interests: polymers; bio-based polymers; polyurethanes; nanocellulose; chitin; polymer composites; polymer nanocomposites; biomimetic materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the modern world, there is a need for materials that are durable, reliable, lightweight, eco-friendly, biocompatible, biodegradable, and have better properties compared to conventional materials. Scientists and engineers have dedicated themselves to research and produce biodegradable and biocompatible polymer materials that can minimize the impact on biomedicine and the environment and expand their applications in these fields. Their efforts have led to the development of numerous polymer materials that are used in water treatment as membranes and in medical devices. These materials also have the potential to contribute significantly to the sustainable development of society due to their renewable nature (some polymers are renewable) and their ability to add value to industry.

In biomedicine, these materials are known to mimic the structures of living materials, improve the properties of matrix materials, and have biocompatibility and biodegradability. The best example of this is the fabrication of scaffolds for bone tissue development. Human bones and tissues are materials with anisotropic properties and biocompatible and biodegradable polymers reinforced with materials which could mimic these structures. In addition to medical applications, a simple and inexpensive process using these materials could completely remove or degrade toxic pollutants and microbes from water within minutes.

We are pleased to invite submissions for the Special Issue, entitled Progress of Biocompatible and Biodegradable Polymersin Biomedicine and Environment. This issue will feature some of the latest advances in the use of polymeric materials. Research areas include (but not limited to) the following: synthesis and extraction of novel biocompatible and biodegradable polymers, tuning their biodegradable behavior, and reinforcement of these polymers with nanomaterials. This involves investigating their antibacterial activity, applications in scaffolds for building bone tissue, and enhanced removal/degradation of toxic pollutants (heavy metals, dyes, microbes) from water. We invite researchers to submit original and review articles on recent advances in the synthesis, extraction, and application of these materials.

We look forward to receiving your contributions.

Dr. Sajjad Haider
Dr. Adnan Haider
Dr. Ainara Saralegi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

sustainable polymers
synthetic biodegradable and biocompatible polymers
regenerative medicine
tissue engineering scaffold
toxicity
antibacterial activity
cellular assay
water treatment
photocatalysts support
organic and inorganic pollutant removal

Published Papers (2 papers)

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Research

15 pages, 4291 KiB

Open AccessArticle

Impact of Diisocyanates on Morphological and In Vitro Biological Efficacy of Eco-Friendly Castor-Oil-Based Water-Borne Polyurethane Dispersions

by Nadia Akram, Muhammad Usman, Sajjad Haider, Muhammad Saeed Akhtar and Kashmala Gul

Polymers 2022, 14(17), 3701; https://doi.org/10.3390/polym14173701 - 5 Sep 2022

Cited by 6 | Viewed by 2001

Abstract

The search for renewable resources that can replace petroleum products is not only nerve-wracking, but also perplexing, as there is an abundance of plants that have yet to be explored. In this project, virgin castor oil was converted to polyol in two steps: epoxidation and hydroxylation. The resulting polyol was used to synthesize two series of water-borne polyurethane dispersions (WPUDs). The effects of the diisocyanates on the final product were evaluated. Isophorone diisocyanate (IPDI) and dicyclohexylmethane-4,4′-diisocyanate (H₁₂MDI) were used as the hard segment (HS) up to 72 wt%, along with 1–4 butanediol (BD) as the chain extender, for the dispersions. Fourier transform infrared spectroscopy (FTIR) confirmed the bonds required for the synthesis of the dispersions. Thermogravimetric analysis (TGA) showed the multistep degradation for both series: maximum degradation took place at 500 °C for IPDI and 600 °C for H₁₂MDI-based series. Scanning electron microscopy (SEM) showed phase-segmented morphology. Hemolytic activity was observed at biologically safe levels of up to 7.5% for H₁₂MDI-based series. Inhibition of biofilm formation showed comparable results against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus): up to 46%. The results were also confirmed by phase contrast microscopy. Full article

(This article belongs to the Special Issue Progress of Biocompatible and Biodegradable Polymers in Biomedicine and Environment)

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13 pages, 2118 KiB

Open AccessArticle

Preparation and Characterization of Hydrophilic Polymer Based Sustained-Release Matrix Tablets of a High Dose Hydrophobic Drug

by Niaz Ali Khan, Amjad Khan, Rooh Ullah, Majeed Ullah, Amal Alotaibi, Riaz Ullah and Adnan Haider

Polymers 2022, 14(10), 1985; https://doi.org/10.3390/polym14101985 - 13 May 2022

Cited by 7 | Viewed by 2571

Abstract

The objective of this study was the preparation and characterization of a sustained-release matrix tablet containing a high-dose hydrophobic drug and its comparison with marketed products. In the present study, HPMC was applied as the matrix-forming polymer for the sustained release of clarithromycin (500 mg). The compatibility of clarithromycin and excipients was studied using a binary mixture approach and compatible excipients were selected. Matrix tablets were prepared using the high-shear wet granulation technique. Tablets were compressed using oblong (19 mm), shallow concave punches, under a compression weight of 900 mg/tablet. The flow of granules was evaluated by determining their bulk density, tapped density, angle of repose, Hausner ratio, and Car’s index. Compressed tablets were tested for their physical parameters, mechanical characteristics, drug content, and in vitro drug release, as per United States Pharmacopeia (USP). Clarithromycin is a drug having poor water solubility and showed compatibility with all the excipients used in the formulation of polymeric matrix tablets. FTIR spectra of clarithromycin, before and after being subjected to the stress conditions, confirmed the compatibility of clarithromycin and other ingredients of the matrix tablets. All the formulations exhibited good rheological characteristics and all the parameters related to flow showed results in the acceptable range. Physically, matrix tablets were smooth and shiny, without any surface defects. Weight variation (±5%) and drug content of the tablets (95–102%) were within the pharmacopeial limits. HPMC successfully sustained the drug release for 24 h. It is concluded from the study that dissolution rate of clarithromycin can be sustained using hydrophilic polymer (HPMC) as a release-controlling agent. Full article

(This article belongs to the Special Issue Progress of Biocompatible and Biodegradable Polymers in Biomedicine and Environment)

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