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Polymers
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Polymer Hydrogels and Nanoparticles in Drug Delivery System
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Polymer Hydrogels and Nanoparticles in Drug Delivery System

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Networks".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 3523

Special Issue Editor

Dr. Yaroslav O. Mezhuev

E-Mail Website
Guest Editor
Institute of Chemistry and Problems of Sustainable Development, Mendeleev University of Chemical Technology of Russia, Moscow 125047, Russia
Interests: conductive polymers; polyaniline; polypyrrole; oxidative polymerization; biomaterials; polymerization kinetics; conductive nanocomposites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of hydrogels and polymer-containing nanoparticles opens up prospects for controlling the drug release rate, the toxicity reduction of drugs, increasing the effectiveness towards the pharmacological target and targeting delivery. The present special issue aims to publish the results of original research and reviews regarding the use of polymer hydrogels and nanomaterials in pharmacology. Manuscripts dedicated to the immobilization of drugs, the kinetics of the release of immobilized drugs, the problems of targeted delivery of pharmacologically active substances and the use of polymer nanomaterials for the treatment of socially significant diseases are welcome. The subject of the special issue brings together any manuscripts devoted to the fundamental and applied aspects of the use of polymer hydrogels, nanoparticles and nanocomposites for the creation of drug delivery systems. Articles dealing with the use of polymer hydrogels in medical applications, tissue replacement, and the creation of wound dressings, suture materials, implants and endoprostheses are also relevant for the special issue.

Dr. Yaroslav O. Mezhuev
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • drug immobilization
  • drug release
  • drug release kinetics
  • cancer therapy
  • antibiotic immobilization
  • drug delivery
  • targeting
  • medicinal chemistry

Published Papers (2 papers)

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Research

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17 pages, 4075 KiB  
Article
Promising Gene Delivery Properties of Polycations Based on 2-(N,N-dimethylamino)ethyl Methacrylate and Polyethylene Glycol Monomethyl Ether Methacrylate Copolymers
by Tatiana P. Loginova, Irina A. Khotina, Yurii A. Kabachii, Sergei Yu. Kochev, Vyacheslav M. Abramov, Valentin S. Khlebnikov, Natalia L. Kulikova and Yaroslav O. Mezhuev
Polymers 2023, 15(14), 3036; https://doi.org/10.3390/polym15143036 - 13 Jul 2023
Viewed by 1241
Abstract
Cationic copolymers based on 2-(N,N-dimethylamino)ethyl methacrylate and polyethylene glycol monomethyl ether (pDMAEMA-co-PEO) with different molecular weights have been synthesized. Their physicochemical properties were studied by NMR spectroscopy, sedimentation, and potentiometric titration. According to the data of potentiometric titration for the synthesized [...] Read more.
Cationic copolymers based on 2-(N,N-dimethylamino)ethyl methacrylate and polyethylene glycol monomethyl ether (pDMAEMA-co-PEO) with different molecular weights have been synthesized. Their physicochemical properties were studied by NMR spectroscopy, sedimentation, and potentiometric titration. According to the data of potentiometric titration for the synthesized pegylated cationic copolymers, the apparent dissociation constants were determined in the pH range from 4.5 to 8.5. The physicochemical properties of interpolyelectrolyte complexes of these polycations with circular DNA (IPEC DNA) were also studied by dynamic light scattering, electrophoretic mobility, and TEM methods. It has been established that the diameter and electrokinetic potential (ζ-potential) of interpolyelectrolyte complexes can be varied over a wide range (from 200 nm to 1.5 μm and from −25 mV to +30 mV) by changing the ratio of oppositely charged ionizable groups in pegylated cationic copolymers and DNA, as well as by regulating medium pH. The resistance of the IPEC DNA/polycation complex to the action of nucleases was studied by electrophoresis in agarose gel; the cytotoxic effect of the polymers in vitro, and the efficiency of penetration (transfection) of IPEC DNA with PDMAEMA-co-PEO-polycations into eukaryotic cells of a cell line derived from human embryonic kidneys HEK 293 in vitro. Full article
(This article belongs to the Special Issue Polymer Hydrogels and Nanoparticles in Drug Delivery System)
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Review

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23 pages, 3212 KiB  
Review
Stimuli-Responsive Protein Hydrogels: Their Design, Properties, and Biomedical Applications
by Yuxuan Lu, Yuhe Chen, Yuhan Zhu, Jingyi Zhao, Ketong Ren, Zhao Lu, Jun Li and Ziyang Hao
Polymers 2023, 15(24), 4652; https://doi.org/10.3390/polym15244652 - 8 Dec 2023
Cited by 1 | Viewed by 1485
Abstract
Protein-based hydrogels are considered ideal biomaterials due to their high biocompatibility, diverse structure, and their improved bioactivity and biodegradability. However, it remains challenging to mimic the native extracellular matrices that can dynamically respond to environmental stimuli. The combination of stimuli-responsive functionalities with engineered [...] Read more.
Protein-based hydrogels are considered ideal biomaterials due to their high biocompatibility, diverse structure, and their improved bioactivity and biodegradability. However, it remains challenging to mimic the native extracellular matrices that can dynamically respond to environmental stimuli. The combination of stimuli-responsive functionalities with engineered protein hydrogels has facilitated the development of new smart hydrogels with tunable biomechanics and biological properties that are triggered by cyto-compatible stimuli. This review summarizes the recent advancements of responsive hydrogels prepared from engineered proteins and integrated with physical, chemical or biological responsive moieties. We underscore the design principles and fabrication approaches of responsive protein hydrogels, and their biomedical applications in disease treatment, drug delivery, and tissue engineering are briefly discussed. Finally, the current challenges and future perspectives in this field are highlighted. Full article
(This article belongs to the Special Issue Polymer Hydrogels and Nanoparticles in Drug Delivery System)
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