Dietary Nitrate in Health and Diseases: Pathways from Nitrate and NOS to Nitric Oxide and Beyond

Dear Colleagues,

We are pleased to announce our plans to publish the following Special Issue of Nutrients: “Dietary Nitrate in Health and Diseases: Pathways from Nitrate and NOS to Nitric Oxide and Beyond”.

The goal of this Special Issue is to bring together authors from different aspects and corners of the nitric oxide (NO) field to create a fresh view of multiple roles of NO and its metabolites in physiology and to highlight functional transformations of NO.

NO metabolism is dysfunctional in many metabolic, cardiovascular, and neuromuscular diseases, and increasing NO can improve the quality of life of some patients. Even healthy people can benefit from increased NO levels, especially aging people and athletes. The NO precursor, nitrate, is found in many vegetables, which allows everybody “in need of increased NO” to profit from simple dietary intervention. So far, research using dietary nitrate has led to conclusions that it is safe; studies either showed a benefit or no change, with no harm detected. However, more clinical research is needed to understand the basic normal physiology of dietary nitrate transformation into nitric oxide and beyond, as well as sites of its dysfunction in diseases.

We aim to publish the most recent developments within the NO field, hopefully even “beyond” NO itself, such as the role of nitrosothiols (famous “SNO”) and nitro-fatty acids. We also hope that new questions and hypotheses about NO transformations arise in this Special Issue of Nutrients.

Dr. Barbora Piknova
Guest Editor

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