Bioinformatics Softwares and Databases for Non-Coding RNA Research

Dear Colleagues,

Eukaryotic genomes encode thousands of small and long non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and pseudogenes. These RNA molecules are emerging as important regulatory molecules in developmental, physiological, and pathological processes. Recent advances in high-throughput next-generation sequencing technologies have provided new biological insights on the complex regulatory mechanisms of ncRNAs as well as enabled the detection and profiling of known and novel ncRNAs at unprecedented sensitivity and depth. Bioinformatics softwares and databases provide powerful ways to integrate massive datasets that produced by high-throughput experiments to identify novel ncRNAs and explore the expression, evolution, modification, regulatory network, structure and function of diverse ncRNAs, and finally to link these ncRNAs to a variety of diseases, such as cancer, metabolic disorders and neurological diseases .

This Special Issue of Non-Coding RNA journal will be devoted to original papers and reviews about bioinformatics softwares and resources for non-coding RNA research.  This issue emphasis on various types of ncRNAs, such as miRNAs, lncRNAs, circRNAs, eRNAs, piRNAs, snoRNAs, endogenous siRNAs, regulatory small RNAs, pseudogenes, tRNA/snoRNA-derived RNA fragments, etc. The scope  of this Special Issue includes, but is not limited to, the following subjects:

• novel databases or resources of non-coding RNAs
• new softwares or pipelines for identifying novel ncRNAs from next-generation sequencing data or genomic sequences
• predicting the functional targets and interacting RNA-Binding Proteins (RBPs) of ncRNAs
• constructing regulatory networks of ncRNAs and inferring their function
• decoding ncRNA structurome from high-throughput sequencing data
• computational analysis of ncRNA modification
• computational identification of disease-related ncRNAs

Prof. JianHua Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.