Pathophysiology and Treatment of Spinal Cord Injury

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Neurology".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 1650

Special Issue Editor


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Guest Editor
1. Department of Rehabilitation Medicine, Keio University School of Medicine, Shinjuku City, Tokyo 160-8582, Japan
2. Department of Rehabilitation Medicine, Kyorin University School of Medicine, Mitaka City 181-8611, Japan
Interests: rehabilitation medicine (stroke, spinal cord injury and Hansen disease); neurorehabilitation; non-invasive transcranial brain stimulation; regenerative rehabilitation; orthotic treatment and robot rehabilitation; disaster rehabilitation; cancer rehabilitation
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Special Issue Information

Dear Colleagues,

Background and history of the topic: Spinal cord injury (SCI) is a devastating event leading to paresis, sensory, autonomic, respiratory, and bowel disturbance that is permanent. There is no established treatment except for surgical procedures to restabilize the spine and decompress the spinal cord in the case of traumatic SCI. Whereas rehabilitative therapies are implemented after the acute treatments, the injured spinal cord exhibits only a small degree of plasticity and functional recovery.

Aim and scope of the Special Issue: The development of a new treatment is important, particularly to target its acute phase to influence the consequences thereafter. Researchers are discovering several points of action to suppress secondary damage in acute SCI, modify the microenvironment, and induce more plasticity toward functional recovery. This Special Issue focuses on newly developing fundamental treatments, including rehabilitative interventions and preventive measures.

Cutting-edge research: Regenerative treatments, Pharmacological treatment for the refractory state of SCI, Neurorehabilitation, etc.

What kind of papers we are soliciting: We are waiting for papers from the field of Neurology and Neurosurgery, Orthopaedic surgery, Urology, and Physical and Rehabilitation Medicine.

Dr. Syoichi Tashiro
Guest Editor

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Keywords

  • stem cells
  • scaffold
  • neurotrophic factor
  • anti-inflammation
  • neurorehabilitation
  • plasticity prevention

Published Papers (1 paper)

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Review

11 pages, 616 KiB  
Review
A Review of Treatment Methods Focusing on Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation for Chronic Spinal Cord Injury
by Takahiro Shibata, Syoichi Tashiro, Masaya Nakamura, Hideyuki Okano and Narihito Nagoshi
Medicina 2023, 59(7), 1235; https://doi.org/10.3390/medicina59071235 - 1 Jul 2023
Cited by 2 | Viewed by 1413
Abstract
Cell transplantation therapy using human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) has attracted attention as a regenerative therapy for spinal cord injury (SCI), and its efficacy in treating the subacute phase of SCI has been reported in numerous studies. However, few [...] Read more.
Cell transplantation therapy using human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) has attracted attention as a regenerative therapy for spinal cord injury (SCI), and its efficacy in treating the subacute phase of SCI has been reported in numerous studies. However, few studies have focused on treatment in the chronic phase, which accounts for many patients, suggesting that there are factors that are difficult to overcome in the treatment of chronic SCI. The search for therapeutic strategies that focus on chronic SCI is fraught with challenges, and the combination of different therapies is thought to be the key to a solution. In addition, many issues remain to be addressed, including the investigation of therapeutic approaches for more severe injury models of chronic SCI and the acquisition of practical motor function. This review summarizes the current progress in regenerative therapy for SCI and discusses the prospects for regenerative medicine, particularly in animal models of chronic SCI. Full article
(This article belongs to the Special Issue Pathophysiology and Treatment of Spinal Cord Injury)
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