Special Issue "Marine Peptides"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (30 April 2010)
Prof. Dr. Frank Mari
Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida, USA
Phone: +1 561 297 3315
Fax: +1 561 297 2759
The marine environment is a vast source of natural products. The biodiversity found in the oceans is remarkable and it has only begun to be explored recently, when compared with terrestrial habitats. The molecular variety associated with this biodiversity represents a challenge for drug discovery. Nevertheless, screening and pharmacological evaluation of marine natural products as potential drug leads has taken a giant leap in the past two decades. As a result, the first drug of marine origin has obtained approval by the FDA on December 31st 2004. Prialt, a peptide (an ω-conotoxin) isolated from a cone snail (Conus magus), has been approved for the treatment of chronic pain as a morphine replacement therapy and it is the most powerful painkiller known to date. This landmark event is evidence that a new wave of “Drugs from the Sea” with novel pharmacologies for the treatment of an array of diseases and conditions is on its way. This issue of Marine Drugs is dedicated to “Marine Peptides”. Whether these compounds are ribosomally-expressed, such as the conotoxins and sea anemone toxins, or enzymatically-produced peptides, they are of great interest as drug leads and for drug development. We hope that the manuscripts here included will cover several aspects of recent developments within the field.
Prof. Dr. Frank Mari
- peptidic natural products
- cone snails
- sea anemones
- structural determination
- peptide synthesis
Mar. Drugs 2011, 9(1), 71-81; doi:10.3390/md9010071
Received: 11 November 2010; in revised form: 16 December 2010 / Accepted: 23 December 2010 / Published: 30 December 2010| Cited by 5 | PDF Full-text (223 KB) | HTML Full-text | XML Full-text
Article: In-Depth Analysis of Exoproteomes from Marine Bacteria by Shotgun Liquid Chromatography-Tandem Mass Spectrometry: the Ruegeria pomeroyi DSS-3 Case-Study
Mar. Drugs 2010, 8(8), 2223-2239; doi:10.3390/md8082223
Received: 7 June 2010; in revised form: 27 July 2010 / Accepted: 28 July 2010 / Published: 29 July 2010| Cited by 9 | PDF Full-text (318 KB) | HTML Full-text | XML Full-text | Supplementary Files
Last update: 27 February 2014