Next Article in Journal
Search for Hydrophilic Marine Fungal Metabolites: A Rational Approach for Their Production and Extraction in a Bioactivity Screening Context
Previous Article in Journal
Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S
Previous Article in Special Issue
In-Depth Analysis of Exoproteomes from Marine Bacteria by Shotgun Liquid Chromatography-Tandem Mass Spectrometry: the Ruegeria pomeroyi DSS-3 Case-Study
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2011, 9(1), 71-81; doi:10.3390/md9010071

Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria

Department of Pharmaceutical Chemistry, NRI Institute of Pharmacy, Bhopal 462 021, Madhya Pradesh, India
*
Authors to whom correspondence should be addressed.
Received: 11 November 2010 / Revised: 16 December 2010 / Accepted: 23 December 2010 / Published: 30 December 2010
(This article belongs to the Special Issue Marine Peptides)
View Full-Text   |   Download PDF [223 KB, uploaded 24 February 2015]   |  

Abstract

The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl-alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-l-Pro-l-Leu-OH and l-Ala-l-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to the naturally occurring compound. Bioactivity results indicated the antifungal and antihelmintic potential of the synthesized peptide against pathogenic dermatophytes and earthworms.
Keywords: natural product synthesis; marine bacteria; cyclic tetrapeptide; biological activity; Halisarca ectofibrosa; Diginea sp. natural product synthesis; marine bacteria; cyclic tetrapeptide; biological activity; Halisarca ectofibrosa; Diginea sp.
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Dahiya, R.; Gautam, H. Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria. Mar. Drugs 2011, 9, 71-81.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top