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Mar. Drugs 2011, 9(1), 71-81; doi:10.3390/md9010071
Article

Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria

*  and *
Department of Pharmaceutical Chemistry, NRI Institute of Pharmacy, Bhopal 462 021, Madhya Pradesh, India
* Authors to whom correspondence should be addressed.
Received: 11 November 2010 / Revised: 16 December 2010 / Accepted: 23 December 2010 / Published: 30 December 2010
(This article belongs to the Special Issue Marine Peptides)
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Abstract

The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl-alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-l-Pro-l-Leu-OH and l-Ala-l-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to the naturally occurring compound. Bioactivity results indicated the antifungal and antihelmintic potential of the synthesized peptide against pathogenic dermatophytes and earthworms.
Keywords: natural product synthesis; marine bacteria; cyclic tetrapeptide; biological activity; Halisarca ectofibrosa; Diginea sp. natural product synthesis; marine bacteria; cyclic tetrapeptide; biological activity; Halisarca ectofibrosa; Diginea sp.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dahiya, R.; Gautam, H. Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria. Mar. Drugs 2011, 9, 71-81.

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