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Mar. Drugs 2011, 9(1), 71-81; doi:10.3390/md9010071
Article

Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria

*  and *
Department of Pharmaceutical Chemistry, NRI Institute of Pharmacy, Bhopal 462 021, Madhya Pradesh, India
* Authors to whom correspondence should be addressed.
Received: 11 November 2010 / Revised: 16 December 2010 / Accepted: 23 December 2010 / Published: 30 December 2010
(This article belongs to the Special Issue Marine Peptides)
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Abstract

The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl-alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-l-Pro-l-Leu-OH and l-Ala-l-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to the naturally occurring compound. Bioactivity results indicated the antifungal and antihelmintic potential of the synthesized peptide against pathogenic dermatophytes and earthworms.
Keywords: natural product synthesis; marine bacteria; cyclic tetrapeptide; biological activity; Halisarca ectofibrosa; Diginea sp. natural product synthesis; marine bacteria; cyclic tetrapeptide; biological activity; Halisarca ectofibrosa; Diginea sp.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Dahiya, R.; Gautam, H. Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria. Mar. Drugs 2011, 9, 71-81.

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