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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases

edited by

Cristina Marginean

submission deadline 20 Oct 2025 | 4 articles | Viewed by 6444 | Submission Open

Keywords: chronic liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); drug-induced liver injury (DILI); hepatocellular carcinoma; biomarkers of liver fibrosis; imaging of liver fibrosis; CEUS; novel therapeutic strategies for CLDs

(This special issue belongs to the Section Medical Research)

Cell-Free DNA as a Biomarker in Metabolic Diseases

edited by

Makrina Karaglani

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2277 | Submission Open

Keywords: cell-free DNA (cfDNA); liquid biopsy; metabolic diseases; obesity; type 2 diabetes; non-alcoholic fatty liver disease (NAFLD); methylation; mutations

(This special issue belongs to the Section Medical Research)

Developments in the Interrelation of Gut Microbiota and Immune System for Treatment Strategies

edited by

Emanuel Vamanu

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1524 | Submission Open

Keywords: gut microbiota; innate immune system; immunotherapy; dysbiosis; bifidobacterium; microbiota modulation; probiotics; prebiotics; symbiotics; postbiotics; cancer immunotherapy; autoimmune diseases; vaccine response; immune regulation; therapeutic microbiology; translational medicine

(This special issue belongs to the Section Medical Research)

Sensitization via Skin Exposure

edited by

Francesca Filon

submission deadline 20 Oct 2025 | Viewed by 206 | Submission Open

Keywords: contact dermatitis; patch test; epidemiology; occupation; prevention

Diversity and Evolution of Pathogenic Viruses

edited by

Yoshiyuki Suzuki

submission deadline 20 Oct 2025 | Viewed by 144 | Submission Open

Keywords: pathogenic viruses; biologic diversity; evolution

(This special issue belongs to the Section Medical Research)

Dive into Myopia

edited by

Chun-Fu Liu

submission deadline 24 Oct 2025 | 1 articles | Viewed by 1201 | Submission Open

Keywords: myopia; hyperopia; myopia control; axial length; axial length retardation; axial length elongation; myopia complications; refraction measurement; atropine; rebound effect; orthokeratology; missight; defocus incorporated multiple segments (DIMSs); highly aspherical lenslets (HALs); red light; repeated low-level red light (RLRL) therapy; enhance myopia control; customized myopia control; peripheral refraction; peripheral myopia; refractive surgery; PRK; LASIK; smile; contact lens; spectacles

(This special issue belongs to the Section Medical Research)

Neuroimaging and Integrative Analyses in Psychiatry and Addictive Disorders

edited by Arkadiusz Komorowski

submission deadline 25 Oct 2025 | Viewed by 276 | Submission Open

Keywords: psychiatry; neuroimaging; forensic psychiatry; fMRI; PET; EEG; addiction; substance use disorders (SUD); psychotherapy; treatment-resistant depression (TRD); attention deficit hyperactivity disorder (ADHD)

(This special issue belongs to the Section Physiology and Pathology)

Laparoscopy and Treatment: An All-Encompassing Solution for Surgeons

edited by Niculae Iordache and Claudiu-Octavian Ungureanu

submission deadline 26 Oct 2025 | 1 articles | Viewed by 1455 | Submission Open

Keywords: oncological; staging laparoscopy; tool; radical surgery; diagnostic

(This special issue belongs to the Section Medical Research)

Therapeutic Effects of Natural Products on Human Diseases: 2nd Edition

edited by

Seung Ho Lee

submission deadline 27 Oct 2025 | 10 articles | Viewed by 27311 | Submission Open

Keywords: natural products; natural extracts; cancer; neurodegenerative diseases; immunological disorders; metabolic diseases; oriental medicine; microorganisms; algae; functional foods

(This special issue belongs to the Section Pharmaceutical Science)

Role of Machine and Deep Learning in Drug Screening

edited by

Shahid Ali

and

Teng Zhou

submission deadline 29 Oct 2025 | Viewed by 656 | Submission Open

Keywords: machine learning in drug screening; deep learning in drug discovery; virtual screening; molecular docking and dynamics; personalized medicine

(This special issue belongs to the Section Pharmaceutical Science)

Soil–Plant–Microbe Interactions: The Role of Biostimulants and Agro-Environmental Implications

edited by Regina Gabilondo and

Ling Zhang

submission deadline 30 Oct 2025 | 3 articles | Viewed by 7739 | Submission Open

Keywords: soil– plant– microbe system; biostimulants; rhizosphere; fertilizers; availability of mineral nutrients; microfaunal grazing; protozoa; nematode; mycorrhizae; microbial loop

(This special issue belongs to the Section Plant Science)

Advances in Integrative Omics Data Analysis for Cancer Research

edited by

Jian Sang

, Jianli Dai and Guangyi Niu

submission deadline 30 Oct 2025 | 2 articles | Viewed by 6325 | Submission Open

Keywords: cancer research; omics; bioinformatics; translational medicine

(This special issue belongs to the Section Genetics and Genomics)

Advances in Anesthesia and Critical Care

edited by

Gabriele Melegari

submission deadline 30 Oct 2025 | 4 articles | Viewed by 3454 | Submission Open

Keywords: anesthesia; intensive care training; updates in anesthesia; machine learning

(This special issue belongs to the Section Medical Research)

Advances in Dryland Agriculture Science

edited by

Liangshan Feng

and Hangyu Dong

submission deadline 30 Oct 2025 | 3 articles | Viewed by 3192 | Submission Open

Keywords: dry farming; climate smart agriculture; soil and water protection; conservation tillage; intercropping; crop rotation; saving irrigation

(This special issue belongs to the Section Plant Science)

Diagnostic Imaging in Colorectal Cancer

edited by

Filippo Crimì

and Chiara Zanon

submission deadline 30 Oct 2025 | 1 articles | Viewed by 2350 | Submission Open

Keywords: colorectal cancer; artificial intelligence; texture analysis; ultrasound; magnetic resonance imaging; PET/MRI

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Optogenetics and Light-Induced Processes in Synthetic Biology

edited by

Pasquale Stano

submission deadline 30 Oct 2025 | Viewed by 760 | Submission Open

(This special issue belongs to the Section Synthetic Biology and Systems Biology)

Personalized Prevention and Treatment in Endocrinology, Diabetes and Metabolic Diseases

edited by Grigorios Panagiotou

submission deadline 31 Oct 2025 | 12 articles | Viewed by 43288 | Submission Open

Keywords: personalized medicine; precision prevention; multi-omics; obesity; diabetes and endocrinology

(This special issue belongs to the Section Medical Research)

Resistance Training Is Medicine

edited by

Daniel J. McDonough

submission deadline 31 Oct 2025 | 4 articles | Viewed by 29484 | Submission Open

Keywords: resistance training; resistance exercise; physical activity; sedentary behavior; strength training; chronic disease; risk factors; obesity; physical health

(This special issue belongs to the Section Epidemiology)

Physical Rehabilitation for Musculoskeletal Disorders

edited by

You Gyoung Yi

submission deadline 31 Oct 2025 | 12 articles | Viewed by 22447 | Submission Open

Keywords: physical rehabilitation; musculoskeletal disorders; pain management; range of motion; muscle strengthening; mobility enhancement; physical therapy; manual therapy; AI in rehabilitation

(This special issue belongs to the Section Medical Research)

Algae—a Step Forward in the Sustainability of Resources: 2nd Edition

edited by

Graciliana Lopes

and

Leonel Pereira

submission deadline 31 Oct 2025 | 9 articles | Viewed by 16973 | Submission Open

Keywords: macroalgae; microalgae; cyanobacteria; bioactive compounds; biomass production; pharmaceuticals; nutraceuticals; cosmetics; food/feed; CO2 sequestrations; water treatment; IMTA; ecosystem services; biofuels; biopesticides; green extraction methods

(This special issue belongs to the Section Microbiology)

Coronary Artery Disease: Pathophysiological Mechanisms, Imaging Modalities and Therapeutic Implications

edited by

Michele Russo

and Filippo Luca Gurgoglione

submission deadline 31 Oct 2025 | 5 articles | Viewed by 11356 | Submission Open

Keywords: coronary artery disease; coronary atherosclerosis; atherosclerotic plaque progression; coronary imaging; cardiovascular risk factors and coronary atherosclerosis-associated diseases

(This special issue belongs to the Section Medical Research)

Recent Advances in Physiotherapy for Musculoskeletal

edited by

Miguel Ángel Rosety-Rodríguez

and

Jorge Góngora-Rodríguez

submission deadline 31 Oct 2025 | 5 articles | Viewed by 10225 | Submission Open

Keywords: musculoskeletal rehabilitation; emerging technologies; virtual reality; artificial intelligence; inflammatory genetics; physiotherapy; sports medicine; functional recovery

(This special issue belongs to the Section Physiology and Pathology)

Orthopedic Disease Treatment and Management: Innovations, Challenges, and Future Directions

edited by Mihnea Ioan Gabriel Popa

submission deadline 31 Oct 2025 | 5 articles | Viewed by 6728 | Submission Open

Keywords: orthopedic surgery; musculoskeletal regeneration; biomaterials and implants; minimally invasive techniques; periprosthetic joint infections; regenerative medicine; biomechanics and implant design; orthopedic trauma and reconstruction; rehabilitation and functional recovery; AI and robotics in orthopedics

(This special issue belongs to the Section Medical Research)

Ecotoxicity Effects of Metals and Microplastics on Aquatic Organisms

edited by Chiara Martino

submission deadline 31 Oct 2025 | 4 articles | Viewed by 5514 | Submission Open

Keywords: aquatic organisms; emerging contaminants; metals; microplastics; defense strategies; cell stress; heavy metals; environmental stress; pollution; ecotoxicology

(This special issue belongs to the Section Animal Science)

Advances and Applications of Sport Physiology: 2nd Edition

edited by

Sime Versic

and

Nikola Foretic

submission deadline 31 Oct 2025 | 4 articles | Viewed by 4957 | Submission Open

Keywords: sports medicine; strength and conditioning; diagnostics; sport injuries; performance analysis

(This special issue belongs to the Section Physiology and Pathology)

Unlocking New Biochemical Pathways: A Bridge for Drug Development in Human and Animal Diseases

edited by

Vincenzo Vestuto

Ignazio Restivo

and

Giuseppe Piegari

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4123 | Submission Open

Keywords: drug discovery; omics sciences; veterinary sciences; oxidative stress; bioactive compounds; inflammation; cancer; neurodegeneration; cell death

(This special issue belongs to the Section Pharmaceutical Science)

Advanced Research in Obstetrics and Gynecology

edited by Vasileios Pergialiotis

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3341 | Submission Open

Keywords: obstetrics; gynecology; gynecologic oncology

(This special issue belongs to the Section Medical Research)

Gynecologic Oncology: Recent Advances and Future Perspectives

edited by Theodoros A. Panoskaltsis and

Alkis Matsas

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3176 | Submission Open

Keywords: gynecologic cancer; gynecologic oncology; biomarkers in gynecology

(This special issue belongs to the Section Medical Research)

Health Management of Farm Animals: Physiological and Pathological Aspects

edited by

Vasileios Papatsiros

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3128 | Submission Open

Keywords: cattle; small ruminants; pig; poultry; veterinary medicine; health; disease; welfare

(This special issue belongs to the Section Animal Science)

Molecular Muscle Adaptations Across the Lifespan

edited by S. Kyle Traivs and

Sime Versic

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2991 | Submission Open

Keywords: muscle tissue; muscle physiology; molecular pathways; therapeutics

(This special issue belongs to the Section Physiology and Pathology)

Bone and Cartilage Fractures: Types, Diagnosis, Complications, Prevention and Treatment

edited by Massimiliano Leigheb, Gabriele Colò and

Giuseppe Basile

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2682 | Submission Open

Keywords: fracture; traumatology; diagnosis; surgery; osteosynthesis; reduction; cartilage; chondral; lesion; injury; rehabilitation; complication

(This special issue belongs to the Section Medical Research)

Advances in Neuroimaging and Functional Brain Analysis

edited by Gianvincenzo Sparacia

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2388 | Submission Open

Keywords: magnetic resonance imaging; resting-state functional magnetic resonance imaging; connectomics; functional connectivity; brain networks; brain diseases assessment

(This special issue belongs to the Section Medical Research)

Microalgae and Their Biotechnological Potential

edited by

Fantao Kong

, Yi Xin and Yuanxue Liang

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2339 | Submission Open

Keywords: microalgae; biofuels; bioproducts; lipid metabolism; synthetic biology; system engineering

(This special issue belongs to the Section Microbiology)

Pediatric Cardiology Frontiers: Innovations in Diagnosis and Treatment

edited by

Eliza Elena Cintezǎ

and

Ştefana Moisǎ

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2332 | Submission Open

Keywords: congenital heart disease; cardiovascular imaging; minimally invasive interventions; fetal cardiology; transcatheter therapies; artificial intelligence in cardiology; 3D echocardiography; cardiac MRI; personalized medicine; genetic heart disorders; heart failure in children; robotic-assisted surgery; cardiovascular biomarkers; electrophysiology in pediatrics; innovative surgical techniques; early diagnosis of heart disease; emerging therapies in cardiology

(This special issue belongs to the Section Medical Research)

The Management and Prognosis of Open-Angle Glaucoma

edited by

Nicoleta Anton

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1897 | Submission Open

Keywords: open-angle glaucoma; cataracts; visual impairment

(This special issue belongs to the Section Medical Research)

Research on Gastrointestinal Cancer and Nutritional Health

edited by

Irene Lidoriki

, Adam Mylonakis and Dimitrios Tsapralis

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1157 | Submission Open

Keywords: dietary patterns; gastrointestinal cancer; clinical nutrition; nutritional status; nutritional assessment; metabolism; gastric cancer; esophageal cancer; pancreatic cancer; colorectal cancer

(This special issue belongs to the Section Medical Research)

Diagnosis and Treatment of Orthopedic Diseases: Advancing Arthroscopy

edited by

Dimitrios A. Flevas

and

Ioannis Gkiatas

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1069 | Submission Open

Keywords: arthroscopy; knee; hip; shoulder; arthroscopic surgery

(This special issue belongs to the Section Medical Research)

Physiological Responses and Adaptation Mechanisms of Plants to Stress

edited by

Jie Luo

and Bassam T. Yasseen

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1035 | Submission Open

Keywords: biotechnology; chemical composition; growth processes; heavy metals; hormonal balance; improving growth variables; mechanisms of osmotic stress; pollution; photosynthesis; stomatal behaviors

(This special issue belongs to the Section Plant Science)

Management of Ischemia and Heart Failure—3rd Edition

edited by

Cristian Mornoş

submission deadline 31 Oct 2025 | 1 articles | Viewed by 986 | Submission Open

Keywords: heart failure; myocardial ischemia; left ventricular remodeling; prognosis

(This special issue belongs to the Section Medical Research)

Research on Viral Infections and Immune Regulation Mechanisms

edited by Moses Turkle Bility

submission deadline 31 Oct 2025 | 1 articles | Viewed by 768 | Submission Open

Keywords: virus infections; virus– host interaction; virome– host interactions; innate immunity; adaptive immunity; host factors in viral infection and immune regulation; acute and chronic infections; restriction factors; viral-vectored strategies; immunotherapeutic strategies against viral infections

(This special issue belongs to the Section Microbiology)

Opportunistic Infections in the Immunocompromised Patient

edited by

Domenico Benvenuto

and Luca Navarini

submission deadline 31 Oct 2025 | Viewed by 412 | Submission Open

Keywords: immunocompromised patients; opportunistic infections; infectious diseases; HIV; immunological mechanisms; epidemiology

(This special issue belongs to the Section Medical Research)

Skin Care and Innovation from the Perspective of Molecular Dermatology

edited by

Ewa Markiewicz

Olusola Idowu

and

Jacek C. Szepietowski

submission deadline 31 Oct 2025 | Viewed by 373 | Submission Open

Keywords: molecular dermatology; personalised skincare; ageing; natural ingredients

(This special issue belongs to the Section Physiology and Pathology)

Metabolic Eye Diseases: From Tomography to Clinical Prediction

edited by

Akio Oishi

and

Nilufer Yesilirmak

submission deadline 31 Oct 2025 | Viewed by 249 | Submission Open

Keywords: metabolic eye diseases; ophthalmic tomography and imaging biomarkers; diabetic retinopathy and systemic metabolic disorders; mitochondrial dysfunction and optic neuropathies; corneal metabolic diseases and ocular surface disorders; artificial intelligence in clinical prediction of eye diseases; metabolic pathways and retinal degeneration; translational research in metabolic ophthalmology

(This special issue belongs to the Section Physiology and Pathology)

Natural Products for the Management of Acute and Chronic Kidney Disease

edited by Noori S. D. Al-Waili

submission deadline 31 Oct 2025 | Viewed by 221 | Submission Open

Keywords: kidney; diseases; management; natural products; proteinuria; bee products

(This special issue belongs to the Section Pharmaceutical Science)

Therapeutic Approaches of Natural Products in Health and Disease

edited by

Mina Mihaylova Todorova

and

Stoyanka Nikolova

submission deadline 31 Oct 2025 | Viewed by 179 | Submission Open

Keywords: natural products; bioactive compounds; isolation; analysis; metabolism; in vitro and in vivo experiments; pharmacological activity

(This special issue belongs to the Section Pharmaceutical Science)

Cutting-Edge Research and Innovation in Gastrointestinal Oncology

edited by Daniela Cornelia Lazar

submission deadline 31 Oct 2025 | Viewed by 155 | Submission Open

Keywords: gastrointestinal oncology; personalized medicine; immunotherapy and targeted treatment; liquid biopsy and molecular biomarkers; artificial intelligence in GI oncology; drug resistance in GI cancer; gut microbiota and cancer progression; endoscopic techniques in GI oncology; modern surgical procedure in GI oncology; multimodal cancer treatment

(This special issue belongs to the Section Physiology and Pathology)

Cross-Species Studies of Cognitive Behaviors: Aspects of Physiological Mechanisms

edited by

Nobuo Masataka

submission deadline 31 Oct 2025 | Viewed by 134 | Submission Open

Keywords: cognitive neuroscience; species-specificity; neural network; brain imaging; communication; social brain; phylogeny

(This special issue belongs to the Section Animal Science)

Urologic Cancer: From Pathophysiology to Therapeutics

edited by

Gianluca Spena

and Roberto Contieri

submission deadline 31 Oct 2025 | Viewed by 118 | Submission Open

Keywords: urologic oncology; robotic surgery; prostate cancer; kidney cancer; bladder cancer; minimally invasive surgery; molecular biomarkers

(This special issue belongs to the Section Medical Research)

Reconstruction of Bone Defects

edited by

Jörg Eschweiler

and

Philipp Kobbe

submission deadline 1 Nov 2025 | 5 articles | Viewed by 6663 | Submission Open

Keywords: bone and fracture biomechanics; bone healing; critical size bone defects; fracture non-union; inflammation; joint arthroplasty and fracture osteosynthesis; implant designs; materials proprieties; patient selection; primary and revision settings

(This special issue belongs to the Section Medical Research)

Breaking the Code: How Genome Sequencing Is Revolutionizing the Diagnosis of Rare Diseases

edited by