Special Issue "Advances in Injectable Biomaterials"

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A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (31 December 2011)

Special Issue Editor

Guest Editor
Prof. Dr. Jons Hilborn

Department of Materials Chemistry, Uppsala University, Box 538, SE-751 21 Uppsala, Sweden
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Published Papers (1 paper)

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Research

Open AccessArticle Sustained Delivery of Chondroitinase ABC from Hydrogel System
J. Funct. Biomater. 2012, 3(1), 199-208; doi:10.3390/jfb3010199
Received: 19 December 2011 / Revised: 27 February 2012 / Accepted: 13 March 2012 / Published: 19 March 2012
Cited by 4 | PDF Full-text (567 KB) | HTML Full-text | XML Full-text
Abstract
In the injured spinal cord, chondroitin sulfate proteoglycans (CSPGs) are the principal responsible of axon growth inhibition and they contribute to regenerative failure, promoting glial scar formation. Chondroitinase ABC (chABC) is known for being able to digest proteoglycans, thus degrading glial scar and
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In the injured spinal cord, chondroitin sulfate proteoglycans (CSPGs) are the principal responsible of axon growth inhibition and they contribute to regenerative failure, promoting glial scar formation. Chondroitinase ABC (chABC) is known for being able to digest proteoglycans, thus degrading glial scar and favoring axonal regrowth. However, its classic administration is invasive, infection-prone and clinically problematic. An agarose-carbomer (AC1) hydrogel, already used in SCI repair strategies, was here investigated as a delivery system capable of an effective chABC administration: the material ability to include chABC within its pores and the possibility to be injected into the target tissue were firstly proved. Subsequently, release kinetic and the maintenance of enzymatic activity were positively assessed: AC1 hydrogel was thus confirmed to be a feasible tool for chABC delivery and a promising device for spinal cord injury topic repair strategies. Full article
(This article belongs to the Special Issue Advances in Injectable Biomaterials)
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