Advances in Mucin Research

Dear Colleagues,

On behalf of the Journal of Clinical Medicine (JCM) Editorial Team, we are delighted to present a new Special Issue on the topic of “Mucins”, Guest Edited by Dr. Christopher Campbell, from Adventist University of Health Sciences in Orlando, Florida.

Mucins are an important immunomodulatory component of the mucous membranes throughout the body. They are characterized by their large polymorphic central domain with tandem repeats rich in serine, threonine, and proline residues. They are the most abundant high molecular weight glycoprotein in mucus and prevent infection by vast numbers of microorganisms. Of the several immunological mechanisms in place to protect mucosal linings from their own microbiota, mucins of the mucous membrane aid in preventing translocation of bacteria to the underlying tissue. In recent years, research has highlighted the role these glycoproteins in cancer diagnosis and therapy. The secreted and transmembrane mucins have been previously found to be involved with inflammation and cancer. Additionally, mucins have demonstrated clinical significance in cystic fibrosis, asthma, and other muco-obstructive airway diseases. Consequently, mucins have been identified as potential therapeutic targets. This Special Issue aims to examine the advances in mucin research, and broaden our understanding of their role in human biology.

Dr. Christopher Campbell
Guest Editor

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