Molecular Pharmacology

Receptor Theory and Drug Binding

• Receptors and Biomolecules: Protein interactions and binding specifics.
• Agonists and Antagonists: Analysis of antagonists and allosteric modulators.
• Affinity and Efficacy: Evaluation of drug affinity, efficacy, and dose–response relationships.

Signal Transduction Pathways

• Pharmacology Basics: Study of transmitters, protein synthesis, and release.
• Cellular Cascades: Intracellular pathways involving G protein-coupled receptors (GPCRs), ion channels, and second messengers.

Pharmacogenomics and Personalized Medicine

• Genetic Impact: How genetic makeup affects individual drug response.
• Metabolic Aberrations: Genetic factors changing drug metabolism and therapeutic efficacy.
• Design Strategies: Using personal genetic information for drug design.

Drug Discovery and Design

• Discovery Methods: Recognition processes, molecular toxicology, and design.
• Structural Approaches: Structure-based drug design and high-throughput screening assays.

Mechanisms of Drug Action and Metabolism

• Molecular Characteristics: Biochemical and biophysical properties affecting biological macromolecules.
• Enzyme Kinetics: Biotransformation pathways and molecular toxicology.

AI Approaches in Personalized Medicine

• Concept Focus: Core concepts and algorithms for new results in AI-based drug design.
• Exclusions: Programming-related topics are omitted from publication scope.