Toll-Like Receptors in Pathologies

Dear Colleagues,

Toll-like receptors (TLRs) belong to pattern recognition receptors expressed by the most cells as transmembrane receptors or within endosomal compartments.

They play a key role in the innate immune system, and their involvement in the several immune and non-immune diseases is currently a matter of great debate and controversy.

Excessive TLR activation can be associated with systemic inflammation, tissue damage, and organ dysfunction.

Cumulative evidence suggests the contribution of TLR signaling dysregulation to the development and progression of almost all diseases, such as neurodegenerative diseases, cancer, chronic inflammation, autoimmune diseases, infectious disease, cardiovascular disorders, inflammatory bowel disease, asthma, obesity, type 2 diabetes mellitus, etc.

This Topical Collection will feature papers on in vitro and animal models of diseases, as well as on patients. The focus is on better understanding the molecular and cellular role of TLRs in the pathogenesis of diseases as well as their potential use as druggable targets for future therapeutics.

Dr. Carmela Conte
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.