Epigenetic Regulation and Antitumor Immune Responses

Dear Colleagues,

The immune system plays a pivotal role in the recognition and killing of tumor cells. Although cancer immune surveillance is irrefutable, it is now recognized that the immune system also shapes the tumor profile—a concept known as immunoediting. Along with tumor progression, tumor is continuously edited by the immune system, while the immune system is simultaneously shaped by the tumor microenvironment. Tumor immune escape mechanisms emerge, namely, downmodulation of antigen presentation machinery and immune cell differentiation into immunosuppressive and dysfunctional phenotypes. This unremitting bidirectional shaping of the tumor/immune system axis is acknowledged to be significantly modulated by epigenetic mechanisms. Hence, the understanding of epigenetic-mediated processes involved in (i) tumor cell escape from immune killing and (ii) the plastic differentiation of immune cells towards dysfunction or immunosuppression is of upmost importance for the understanding of tumor biology, and for the design of novel therapeutic strategies targeting epigenetic mechanisms. Thus, in this Special Issue, we aim to cover all relevant aspects involved in cancer immunoepigenetics and immune escape, including basic and translational research.

Prof. Dr. Carmen Jerónimo
Dr. Jesús M. Paramio
Dr. Margareta P. Correia
Guest Editors

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• immunoepigenetics
• tumor immune escape
• epigenetics
• tumor immunology
• immunoediting
• immune cell dysfunction
• tumor microenvironment
• immune suppression