Extracellular Matrix in Wound Healing
A special issue of Bioengineering (ISSN 2306-5354).
Deadline for manuscript submissions: closed (31 July 2019) | Viewed by 6353
Special Issue Editors
Interests: Human pluripotent stem cells differentiation; Modeling inflammation and macrophage polarization; Studying interactions between tissue engineered devices and the host tissue response
Special Issues, Collections and Topics in MDPI journals
Interests: Tissue engineering scaffolds that positively modulate the wound healing host response; cell therapy in combination with scaffold materials; macrovesicle carriers; and antimicrobial agents’ development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The derivation of tissue specific extracellular matrix scaffolds (ECM-scaffolds) represent an exciting approach to biomaterial design since it relies on the natural design and composition of the tissue of interest. If the ECM-scaffold is derived with minimal processing to yield an implantable material with low DNA content and low immunogenicity, it may also retain important cell and tissue signaling molecules and macromolecules that help modulate cell behavior in vitro and promote healing during the host tissue response in vivo. Although the clinical utility of ECM-scaffolds has been well established, the biological reasons for such response remains elusive. Understanding the mechanism behind the cellular recognition that leads to a specific cellular response in vivo and in vitro will expand our understanding behind the clinical success and failures of these biomaterials. It would also help improve current decellularization protocols that could lead to superior ECM-scaffolds and enhance healing and constructive remodeling.
The special issue will focus on mechanistic studies looking at:
- Derivation of tissue specific ECM scaffolds with an emphasis on mechanistic reasons for the enhanced tissue response
- Compositional analysis and comparisons of ECM scaffolds
- Use of ECM-scaffolds to create in vitro testing platforms
- Role of tissue specificity on stem cell differentiation in vitro
- Role of tissue specificity on host tissue response
- ECM-scaffold directed stem cell differentiation
- Mechanism for macrophage polarization in vitro and in vivo
- Mechanisms for scar tissue inhibition
Dr. Camilo Mora-Navarro
Guest Editors
Manuscript Submission Information
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