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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Revolutionizing Infection Treatment: Cutting-Edge Approaches in Antimicrobial Stewardship

edited by Jacob Myles Keck and

Aleksandra Barac

submission deadline 30 Oct 2025 | 3 articles | Viewed by 2712 | Submission Open

Keywords: antimicrobial stewardship; antimicrobial resistance; infection treatment optimization; rapid diagnostics; technology in healthcare

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobial Resistance and Epidemiological Study of Clinically Relevant Pathogens

edited by

Florin George Horhat

Adrian Man

and

Delia Muntean

submission deadline 31 Oct 2025 | 9 articles | Viewed by 26745 | Submission Open

Keywords: antibacterial activity; antimicrobial resistance; infections; multidrug-resistant pathogens; virulence gene expression; drug discovery; epidemiological study

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobials Agents: Latest Advances and Prospects

edited by

Marius Stefan

submission deadline 31 Oct 2025 | 7 articles | Viewed by 25987 | Submission Open

Keywords: multidrug-resistant pathogens; infectious diseases; antibiotic resistance; new antimicrobials; drug development; antimicrobial activity; structure– activity relationship (SAR); antimicrobial therapy

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiofilm Activity against Multidrug-Resistant Pathogens

edited by

Verica Aleksic Sabo

and Petar Knezevic

submission deadline 31 Oct 2025 | 7 articles | Viewed by 22208 | Submission Open

Keywords: biofilm; microbial drug resistance; antibiofilm agents; antibiofilm strategies; synergistic interactions

(This special issue belongs to the Section Antibiofilm Strategies)

Antimicrobial Resistance in Clinical Infection and Antibiotic Stewardship

edited by

Daniel T. Anderson

submission deadline 31 Oct 2025 | 6 articles | Viewed by 21770 | Submission Open

Keywords: antimicrobial stewardship; antimicrobial resistance; treatment; antimicrobials

Mechanism of Carbapenem Resistance in Enterobacteriaceae, Acinetobacter and Pseudomonas aeruginosa

edited by

Ágnes Pál-Sonnevend

submission deadline 31 Oct 2025 | 5 articles | Viewed by 17732 | Submission Open

Keywords: gram-negative infections; mechanism of carbapenem resistance; molecular epidemiology; in vitro diagnostic tools; antimicrobial treatment; beta-lactam/beta lactamase inhibitors; cefiderocol

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Diagnosis and Antimicrobial Therapy of Osteoarticular Infection

edited by Janet D. Conway

submission deadline 31 Oct 2025 | 5 articles | Viewed by 16456 | Submission Open

Keywords: bone infection; joint infection; periprosthetic joint infection; orthopaedic infection; orthopedic infection

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antibiotic Use in the Communities—2nd Edition

edited by

Timo Juhani Lajunen

and

Mark Sullman

submission deadline 31 Oct 2025 | 8 articles | Viewed by 14421 | Submission Open

Keywords: antibiotic use; community; behavior; socioeconomic factors; culture; values

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Insights into Natural Antimicrobial Peptides

edited by

András Fodor

Eustachio Tarasco

and

Maurizio Francesco Brivio

submission deadline 31 Oct 2025 | 4 articles | Viewed by 14330 | Submission Open

Keywords: antibacterial host defense peptides; antibacterial mode of action; defensins; cathelicidins; insect antimicrobial peptides; plant antimicrobial peptides

(This special issue belongs to the Section Antimicrobial Peptides)

New Paradigms Concerning the Production of Antibiotics: Between Ecological Responsibility and Revalorization of Narrow Spectrums

edited by

Véronique Mondain

submission deadline 31 Oct 2025 | 3 articles | Viewed by 10036 | Submission Open

Keywords: one health; environmental pollution; human health; antimicrobial production; livestock; antimicrobial resistance; antimicrobial stewardship

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Antibiotic Resistance: From the Bench to Patients, 2nd Edition

edited by

Fernando Albericio

and

Márió Gajdács

submission deadline 31 Oct 2025 | 3 articles | Viewed by 9325 | Submission Open

Keywords: antimicrobial resistance; infectious disease epidemiology; multidrug resistance; clinical bacteriology; antimicrobial stewardship; self-medication; knowledge– attitude– practice (KAP); regulatory perspectives; drug utilization; policy analysis; primary care; pharmacy; novel antimicrobial drugs; laboratory testing

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

New Approaches in Antimicrobial Drug Discovery and Design

edited by

Robert Penchovsky

submission deadline 31 Oct 2025 | 2 articles | Viewed by 8401 | Submission Open

Keywords: rational drug design; multi-drug resistant human pathogenic bacteria; new antibiotics; antibacterial drugs; antibacterial drug targets; in silico drug target evaluation

(This special issue belongs to the Section Novel Antimicrobial Agents)

Strategies to Combat Antibiotic Resistance and Microbial Biofilms

edited by

Isabella Macário Ferro Cavalcanti

submission deadline 31 Oct 2025 | 4 articles | Viewed by 8377 | Submission Open

Keywords: antibiotic resistance; biofilms; nanotechnology; medicinal plants; synthetic

(This special issue belongs to the Section Novel Antimicrobial Agents)

Biofilms and Urinary Tract Infections

edited by

Dino Sgarabotto

and

Anabela Borges

submission deadline 31 Oct 2025 | 1 articles | Viewed by 8264 | Submission Open

(This special issue belongs to the Section Antibiofilm Strategies)

Microbial Natural Products as a Source of Novel Antimicrobials, 2nd Edition

edited by

Patricia Branco

and

Elisabete Muchagato Mauricio

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4724 | Submission Open

Keywords: antimicrobial peptides; mycocins; bacteriocins; antimicrobial activity; biopreservatives

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotics: Utilization, Resistance, and Infection Prevention

edited by

Tafadzwa Dzinamarira

and

Claude Mambo Muvunyi

submission deadline 31 Oct 2025 | 1 articles | Viewed by 4097 | Submission Open

Keywords: antibiotic resistance; antimicrobial stewardship; infection prevention; antibiotic stewardship programs; antimicrobial resistance mechanisms; infection control; rapid diagnostics; public health and AMR; antibiotic alternatives; surveillance systems

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobial Resistance and Zoonoses, 2nd Edition

edited by

Marina Spînu

and

Magdalena Rzewuska

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3972 | Submission Open

Keywords: antibiotics; antimicrobial resistance; antimicrobial resistance genes; monitoring; one health; pathogen transmission; resistance mechanisms; surveillance; zoonotic pathogens; zoonosis

Genetics and Antimicrobial Resistance in Pathogens of Hospital Importance

edited by

Maria de Lourdes Ribeiro de Souza da Cunha

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3730 | Submission Open

Keywords: ESKAPEE pathogens; antimicrobial resistance; multidrug-resistant organisms; genetics; resistance mechanisms

(This special issue belongs to the Section Genetic and Biochemical Studies of Antibiotic Activity and Resistance)

ESKAPE and MDRO Pathogens: Infections and Antimicrobial Treatment

edited by

Carlo Pallotto

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2563 | Submission Open

Keywords: ESKAPE; MDRO; Escherichia coli; Staphylococcus aureus; Klebsiella pneumoniae; Acinetobacter baumannii; Pseudomonas aeruginosa; Enterococcus faecalis; Enterococcus faecium; Stenotrophomonas maltophilia; Enterobacter cloacae; antimicrobial stewardship

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Environmental Fate and Effects of Antibiotics and Antibiotic Resistance Genes, 2nd Edition

edited by

Anna Barra Caracciolo

and Ludovica Rolando

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2413 | Submission Open

Keywords: antibiotic-resistant bacteria; antibiotic resistance genes; environmental spread; bioaccumulation; biodegradation; antibiotic mixture

Novel Antimicrobial Strategies to Combat Multidrug-Resistant (MDR) Gram-Negative Bacteria, 2nd Edition

edited by

Valerie Carabetta

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2062 | Submission Open

Keywords: gram negative; antibiotic resistance; antiseptic resistance; multidrug resistant; extensively drug resistant; pandrug resistant; MDR; XDR; PDR; efflux pumps; mechanisms of resistance; beta-lactamase; outer membrane

Antibiotics and Antimicrobial Resistance in Aquaculture: Alternative and Complementary Treatment Methods

edited by

Jaime Romero

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2055 | Submission Open

Keywords: antibiotics; antimicrobial resistance; alternatives; aquaculture; probiotics; phage therapy

Prevalence, Treatment and Antibacterial Resistance of Urinary Tract Infections

edited by Alin Gabriel Mihu and

Tudor Rares Olariu

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1855 | Submission Open

Keywords: urinary tract infections; UTI; antibiotic; antibacterial; resistance; uropathogens; recurrent UTI; Enterobacteriaceae; Escherichia coli

Structure and Function of Antimicrobial Peptides

edited by Daniel Balleza and

Gill Diamond

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1731 | Submission Open

Keywords: antimicrobial peptides; natural peptides; lipidomics; synergistic action; bioactivity mechanisms; structure reconfiguration

(This special issue belongs to the Section Antimicrobial Peptides)

Essential Oils as Natural Antimicrobials: Extraction, Characterization, and Synergistic Applications

edited by

Sergio A. Rodríguez

, Axel Hollmann and

Douglas Siqueira de Almeida Chaves

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1678 | Submission Open

Keywords: natural antimicrobials; biofilm eradication; mechanism of action; synergism; antagonism; cytotoxicity; compound isolation; membrane interaction; enzymatic inhibition; DNA interaction; oxidative stress

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antibiotics in the Environment: Sources, Fate, and Mitigation Strategies

edited by Khaled Benis

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1558 | Submission Open

Keywords: antibiotic contamination; environmental fate; antibiotic resistance; mitigation strategies; pollution management

The Application of Antibiotic Therapy in Oral Surgery and Dental Implant Procedures, 2nd Edition

edited by

Angel-Orion Salgado-Peralvo

and

Eugenio Velasco-Ortega

submission deadline 31 Oct 2025 | 1 articles | Viewed by 959 | Submission Open

Keywords: antibiotics; preventive antibiotic therapy; antibiotic prophylaxis; bacterial antibiotic resistance; antibiotic resistance; oral implantology; dental implantology; dental implants; dentistry; oral surgery

Etiology, Clinical Presentation, Antibiotic and Surgical Treatment of Infective Endocarditis

edited by Francesco Santini,

Francesco Onorati

and

Antonio Salsano

submission deadline 31 Oct 2025 | Viewed by 645 | Submission Open

Keywords: infective endocarditis; acute; bacterial; diagnosis; treatment; valvular heart disease; cardiac surgery; cardiac prosthesis; complications; intensive care

Pathogenesis, Epidemiology and Antibiotic Resistance of Salmonella

edited by

Angela Pista

and

Leonor Silveira

submission deadline 31 Oct 2025 | Viewed by 561 | Submission Open

Keywords: Salmonella; epidemiology; genomics; public health; antimicrobial resistance; One-Health approach

Antimicrobial Activity of Natural Products and Plants Extracts, 2nd Edition

edited by

Mihaela Niculae

and

Daniela Hanganu

submission deadline 31 Oct 2025 | Viewed by 282 | Submission Open

Keywords: natural products; plant extracts; bioactive compounds; phytoconstituents; antibacterial efficacy; in vitro screening; in vivo evaluation; antibiofilm; anti-quorum

(This special issue belongs to the Section Plant-Derived Antibiotics)

Novel Preventive and Therapeutic Strategies to Eradicate Biofilm Infections Based on New Antibacterial Compounds

edited by

María Guembe

submission deadline 31 Oct 2025 | Viewed by 175 | Submission Open

Keywords: antibacterial; biofilm; infection; innovation; microbiota

(This special issue belongs to the Section Antibiofilm Strategies)

Metal-Based Antibiotics and Therapeutics

edited by

Sotiris K Hadjikakou

and

Christina N. Banti

submission deadline 31 Oct 2025 | Viewed by 161 | Submission Open

Keywords: biological inorganic chemistry; metallotherapeutics; metal-based antibiotics; antimicrobial compounds; antimicrobial resistance (AMR); antimicrobials materials or nanoparticles; active medical devices

(This special issue belongs to the Section Novel Antimicrobial Agents)

Biotechnological Production of Novel Antimicrobials

edited by

Vanja Vlajkov

Jovana Grahovac

and

Ivana Danilov

submission deadline 1 Nov 2025 | 1 articles | Viewed by 1397 | Submission Open

Keywords: antibiotic resistance; biotechnology; antimicrobial activity; disease outbreak; pathogens; microorganisms; genetic engineering; artificial intelligence; optimisation; biocontrol

A Themed Issue in Honor of Professor Helen Giamarellou—Outstanding Contributions in the Fields of Antimicrobial Resistance and Difficult-to-Treat Resistance Pathogens

edited by Konstantinos Pontikis

submission deadline 5 Nov 2025 | 6 articles | Viewed by 19079 | Submission Open

Keywords: antibiotic stewardship; nosocomial infections; infection control; epidemiology of resistance plus in vitro investigation of underlying resistance mechanisms; infections in the ICU; neutropenic host infections; indicated therapeutic approach of MDR and XDR gram-negative infections; pharmacokinetics/pharmacodynamics of newer antimicrobial agents

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

New Natural Products as Candidates for the Discovery of Antimicrobial Drugs

edited by

Maya Zaharieva

and

Hristo Najdenski

submission deadline 15 Nov 2025 | 5 articles | Viewed by 24934 | Submission Open

Keywords: natural products; antimicrobial mechanisms and strategies; combination effects; clinical applicability; in silico; in vitro and in vivo models; infection control

(This special issue belongs to the Section Plant-Derived Antibiotics)

Pathogenic Microorganisms and Antibiotic Therapy in Infectious Disease

edited by

Angela Quirino

Grazia Pavia

and

Nadia Marascio

submission deadline 15 Nov 2025 | 2 articles | Viewed by 5778 | Submission Open

Keywords: antimicrobial resistance; pathogenic mechanisms; multidrug-resistant microorganisms; antimicrobial drugs; innovative therapeutic strategies

The Battle Against Urinary Tract Infections: The Role of Antibiotics

edited by

Pawel Miotla

and

Sara Wawrysiuk

submission deadline 15 Nov 2025 | 1 articles | Viewed by 2166 | Submission Open

Keywords: urinary tract infection (UTI); antibiotics; antimicrobial resistance (AMR); multidrug-resistant uropathogens; antibiotic stewardship; UTI treatment; novel antibiotics; phage therapy; UTI pathogenesis; probiotics in UTI management

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antimicrobial Resistance in Aquaculture: Balancing Health and Sustainability

edited by

Zhigang Zhou

submission deadline 15 Nov 2025 | 1 articles | Viewed by 476 | Submission Open

Keywords: antimicrobial resistance; aquaculture; one health approach; antibiotic stewardship; probiotics; zoonotic pathogens; resistance genes; sustainable practices; environmental impact

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Biomaterials for Dentistry

edited by

Edith Lara-Carrillo

submission deadline 18 Nov 2025 | Viewed by 256 | Submission Open

Keywords: antimicrobials; dentistry; microorganisms; biomaterials; caries risk; oral environment; epidemiology

Genomic Analysis of Antimicrobial Drug-Resistant Bacteria

edited by

Maria Rosario Rodicio

and

Carlos Rodriguez-Lucas

submission deadline 30 Nov 2025 | 7 articles | Viewed by 17173 | Submission Open

Keywords: antimicrobial drug resistance; whole-genome sequencing; genomic epidemiology; one health; bacterial pathogens; mobile genetic elements; horizontal gene transfer; phylogenetics; evolution

(This special issue belongs to the Section Genetic and Biochemical Studies of Antibiotic Activity and Resistance)

Bioactive Peptides and Their Antibiotic Activity

edited by

Hamilton Cabral

submission deadline 30 Nov 2025 | 9 articles | Viewed by 15133 | Submission Open

Keywords: database peptides; therapeutic agents; peptide design; antimicrobial peptides; antibiotic resistance; therapeutic drugs

(This special issue belongs to the Section Antimicrobial Peptides)

Environmental Fate of Antibiotics: Monitoring, Toxicity, Resistance, and Removal Methods

edited by

Takashi Azuma

submission deadline 30 Nov 2025 | 5 articles | Viewed by 13546 | Submission Open

Keywords: antimicrobials; high-throughput analysis; wastewater treatment plant (WWTP); hospital wastewater; livestock environment; water purification plant (WTP); aquatic environment; environmental health risk assessment; antimicrobial resistance (AMR); advanced water treatment

Antibiotic Resistance and Virulence Mechanisms in Gram-Negative Bacteria: An Alliance for Success

edited by

Francesco Imperi

submission deadline 30 Nov 2025 | 8 articles | Viewed by 12996 | Submission Open

Keywords: virulence; Gram-negative; antimicrobial resistance; One Health

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Managing Appropriate Antibiotic Prescribing and Use in Primary Care

edited by

Ruby Biezen

submission deadline 30 Nov 2025 | 5 articles | Viewed by 9712 | Submission Open

Keywords: primary care; general practice; antimicrobial stewardship; antimicrobial resistance; infectious disease; appropriate prescribing; guidelines concordance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Development of Antimicrobial Peptides from Amphibian, 2nd Edition

edited by

Maria Luisa Mangoni

Bruno Casciaro

and Maria Rosa Loffredo

submission deadline 30 Nov 2025 | 4 articles | Viewed by 7924 | Submission Open

Keywords: frog skin-derived antimicrobial peptides; natural and synthetic AMPs; the synergy of AMPs; insights into the mechanism(s) of action of AMPs; drug delivery system

(This special issue belongs to the Section Antimicrobial Peptides)

Comprehensively Addressing Antimicrobial Resistance, Improving Food Safety and Achieving the One Health Goals: Global Challenges

edited by

Vladimir Kurćubić

, Pavle Mašković,

Milan N. Mitić

and

Nikola Stanišić

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6685 | Submission Open

Keywords: antimicrobial resistance (AMR); food safety; foodborne pathogens; antibiotic residues; natural antimicrobials; one health

Antibiotic and Antiparasitic Resistance in Veterinary Clinical Settings

edited by

Daphne Lianou

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5966 | Submission Open

Keywords: animal; cattle; cat; dog; goat; horse; pig; poultry; sheep; therapeutics; treatment; veterinary; wildlife

(This special issue belongs to the Section Antibiotics in Animal Health)

Therapeutic Drug Monitoring of Antimicrobials in Critically Ill Patients

edited by Young Ran Lee

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5810 | Submission Open

Keywords: therapeutic drug monitoring (TDM); antibiotics; antimicrobials; pharmacokinetic; pharmacodynamic; critically ill

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

The Antimicrobial Resistance in the Food Chain

edited by

Irene Dini

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4637 | Submission Open

Keywords: food safety; foodborne pathogens; pathways of antimicrobial resistance; antibiotic resistance; phenotypic analyses; molecular analyses; regulatory guidelines; food chemistry

Bacteriophages and Phage-Derived Enzymes as Antibacterial Agents

edited by

Grzegorz Wegrzyn

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4210 | Submission Open

Keywords: phage therapy; lytic bacteriophages; phage-derived enzymes; antibiotic resistance

(This special issue belongs to the Section Bacteriophages)

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