Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways
AbstractHypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neural activity may induce hypoxia-regulated genes and how miR-210 may regulate plasticity in more complex mammalian systems. Using a pull-down approach, we identified 620 unique target genes of miR-210 in humans, among which there was a significant enrichment of age-related neurodegenerative pathways, including Huntington’s, Alzheimer’s, and Parkinson’s diseases. We have also validated that miR-210 directly regulates various identified target genes of interest involved with neuronal plasticity, neurodegenerative diseases, and miR-210-associated cancers. This data suggests a potentially novel mechanism for how metabolic changes may couple plasticity to neuronal activity through hypoxia-regulated genes such as miR-210. View Full-Text
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Watts, M.E.; Williams, S.M.; Nithianantharajah, J.; Claudianos, C. Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways. Non-Coding RNA 2018, 4, 10.
Watts ME, Williams SM, Nithianantharajah J, Claudianos C. Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways. Non-Coding RNA. 2018; 4(2):10.Chicago/Turabian Style
Watts, Michelle E.; Williams, Sarah M.; Nithianantharajah, Jess; Claudianos, Charles. 2018. "Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways." Non-Coding RNA 4, no. 2: 10.
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