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Non-Coding RNA 2016, 2(1), 1; doi:10.3390/ncrna2010001

The Ins and Outs of miRNA-Mediated Gene Silencing during Neuronal Synaptic Plasticity

Department of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK
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Academic Editor: George A. Calin
Received: 23 October 2015 / Revised: 11 December 2015 / Accepted: 15 December 2015 / Published: 11 January 2016
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Abstract

Neuronal connections through specialized junctions, known as synapses, create circuits that underlie brain function. Synaptic plasticity, i.e., structural and functional changes to synapses, occurs in response to neuronal activity and is a critical regulator of various nervous system functions, including long-term memory formation. The discovery of mRNAs, miRNAs, ncRNAs, ribosomes, translational repressors, and other RNA binding proteins in dendritic spines allows individual synapses to alter their synaptic strength rapidly through regulation of local protein synthesis in response to different physiological stimuli. In this review, we discuss our understanding of a number of miRNAs, ncRNAs, and RNA binding proteins that are emerging as important regulators of synaptic plasticity, which play a critical role in memory, learning, and diseases that arise when neuronal circuits are impaired. View Full-Text
Keywords: synaptic plasticity; synopase; miRNAs; ncRNAs; RNA binding proteins synaptic plasticity; synopase; miRNAs; ncRNAs; RNA binding proteins
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Rajgor, D.; Hanley, J.G. The Ins and Outs of miRNA-Mediated Gene Silencing during Neuronal Synaptic Plasticity. Non-Coding RNA 2016, 2, 1.

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