Are We Eating Our Way to Prostate Cancer—A Hypothesis Based on the Evolution, Bioaccumulation, and Interspecific Transfer of miR-150
Abstract
:1. Introduction
2. miR-150 and Cancer
3. miR-150: A Potential Biomarker for Prostate Cancer
4. Past and Present Genome Scenario
5. Interspecific Mechanisms of miRNA Evolution and Accumulation as the Species Advances
- (i)
- Situation 1 describes the direct uptake of miR-150 from pathogens to humans.
- (ii)
- Situation 2 describes the uptake of miR-150 from pathogens by plants and to humans through oral transfer (eating).
- (iii)
- Situation 3 describes the uptakes of miR-150 by cattle and then humans by consumption of either meat or by the consumption of milk and dairy products [62].
- (iv)
- Situation 4 describes the uptake of miR-150 from pathogens to plants, then by cattle (grazing) and finally humans by considering the food web/trophic levels.
6. Pathogens
7. Nutrition
8. Mechanism of Action
9. Conclusions
Acknowledgements
Author Contributions
Conflicts of Interest
References
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Vaidyanathan, V.; Krishnamoorthy, V.; Karunasinghe, N.; Jabed, A.; Pallati, R.; Kao, C.H.-J.; Wang, A.; Marlow, G.; Ferguson, L.R. Are We Eating Our Way to Prostate Cancer—A Hypothesis Based on the Evolution, Bioaccumulation, and Interspecific Transfer of miR-150. Non-Coding RNA 2016, 2, 2. https://doi.org/10.3390/ncrna2020002
Vaidyanathan V, Krishnamoorthy V, Karunasinghe N, Jabed A, Pallati R, Kao CH-J, Wang A, Marlow G, Ferguson LR. Are We Eating Our Way to Prostate Cancer—A Hypothesis Based on the Evolution, Bioaccumulation, and Interspecific Transfer of miR-150. Non-Coding RNA. 2016; 2(2):2. https://doi.org/10.3390/ncrna2020002
Chicago/Turabian StyleVaidyanathan, Venkatesh, Vetrivhel Krishnamoorthy, Nishi Karunasinghe, Anower Jabed, Radha Pallati, Chi Hsiu-Juei Kao, Alice Wang, Gareth Marlow, and Lynnette R. Ferguson. 2016. "Are We Eating Our Way to Prostate Cancer—A Hypothesis Based on the Evolution, Bioaccumulation, and Interspecific Transfer of miR-150" Non-Coding RNA 2, no. 2: 2. https://doi.org/10.3390/ncrna2020002