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Non-Coding RNA, Volume 2, Issue 1 (March 2016) – 1 article

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Review
The Ins and Outs of miRNA-Mediated Gene Silencing during Neuronal Synaptic Plasticity
by Dipen Rajgor and Jonathan G. Hanley
Non-Coding RNA 2016, 2(1), 1; https://doi.org/10.3390/ncrna2010001 - 11 Jan 2016
Cited by 12 | Viewed by 5806
Abstract
Neuronal connections through specialized junctions, known as synapses, create circuits that underlie brain function. Synaptic plasticity, i.e., structural and functional changes to synapses, occurs in response to neuronal activity and is a critical regulator of various nervous system functions, including long-term memory [...] Read more.
Neuronal connections through specialized junctions, known as synapses, create circuits that underlie brain function. Synaptic plasticity, i.e., structural and functional changes to synapses, occurs in response to neuronal activity and is a critical regulator of various nervous system functions, including long-term memory formation. The discovery of mRNAs, miRNAs, ncRNAs, ribosomes, translational repressors, and other RNA binding proteins in dendritic spines allows individual synapses to alter their synaptic strength rapidly through regulation of local protein synthesis in response to different physiological stimuli. In this review, we discuss our understanding of a number of miRNAs, ncRNAs, and RNA binding proteins that are emerging as important regulators of synaptic plasticity, which play a critical role in memory, learning, and diseases that arise when neuronal circuits are impaired. Full article
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