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Gels 2015, 1(2), 135-161;

Magnetic Gel Composites for Hyperthermia Cancer Therapy

Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, Regensburg 93040, Germany
IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain
The Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Jordi Girona 18-26, Barcelona 08034, Spain
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Rolando Barbucci
Received: 31 August 2015 / Accepted: 2 September 2015 / Published: 30 September 2015
(This article belongs to the Special Issue Nanoparticle-Hydrogel Composites for Biomedical Applications)
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Hyperthermia therapy is a medical treatment based on the exposition of body tissue to slightly higher temperatures than physiological (i.e., between 41 and 46 °C) to damage and kill cancer cells or to make them more susceptible to the effects of radiation and anti-cancer drugs. Among several methods suitable for heating tumor areas, magnetic hyperthermia involves the introduction of magnetic micro/nanoparticles into the tumor tissue, followed by the application of an external magnetic field at fixed frequency and amplitude. A very interesting approach for magnetic hyperthermia is the use of biocompatible thermo-responsive magnetic gels made by the incorporation of the magnetic particles into cross-linked polymer gels. Mainly because of the hysteresis loss from the magnetic particles subjected to a magnetic field, the temperature of the system goes up and, once the temperature crosses the lower critical solution temperature, thermo-responsive gels undergo large volume changes and may deliver anti-cancer drug molecules that have been previously entrapped in their networks. This tutorial review describes the main properties and formulations of magnetic gel composites conceived for magnetic hyperthermia therapy. View Full-Text
Keywords: hydrogel; composites; magnetic nanoparticles; hyperthermia; cancer therapy; drug delivery hydrogel; composites; magnetic nanoparticles; hyperthermia; cancer therapy; drug delivery

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Häring, M.; Schiller, J.; Mayr, J.; Grijalvo, S.; Eritja, R.; Díaz, D.D. Magnetic Gel Composites for Hyperthermia Cancer Therapy. Gels 2015, 1, 135-161.

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