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Gels 2015, 1(1), 69-80; doi:10.3390/gels1010069

Composite Chitosan/Agarose Ferrogels for Potential Applications in Magnetic Hyperthermia

1
Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC) c/ Juan de la Cierva 3, 28006 Madrid, Spain
2
CENIMAT/I3N, Departamento de Ciência dos Materiais, Faculdade de Ciências e Tecnologia, FCT, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editor: Rolando Barbucci
Received: 12 May 2015 / Revised: 12 June 2015 / Accepted: 3 July 2015 / Published: 9 July 2015
(This article belongs to the Special Issue Nanoparticle-Hydrogel Composites for Biomedical Applications)
View Full-Text   |   Download PDF [1391 KB, uploaded 10 July 2015]   |  

Abstract

Composite ferrogels were obtained by encapsulation of magnetic nanoparticles at two different concentrations (2.0 and 5.0 % w/v) within mixed agarose/chitosan hydrogels having different concentrations of agarose (1.0, 1.5 and 2.0% (w/v)) and a fixed concentration of chitosan (0.5% (w/v)). The morphological characterization carried out by scanning electron microscopy showed that dried composite ferrogels present pore sizes in the micrometer range. Thermogravimetric measurements showed that ferrogels present higher degradation temperatures than blank chitosan/agarose hydrogels without magnetic nanoparticles. In addition, measurements of the elastic moduli of the composite ferrogels evidenced that the presence of magnetic nanoparticles in the starting aqueous solutions prevents to some extent the agarose gelation achieved by simply cooling chitosan/agarose aqueous solutions. Finally, it is shown that composite chitosan/agarose ferrogels are able to heat in response to the application of an alternating magnetic field so that they can be considered as potential biomaterials to be employed in magnetic hyperthermia treatments. View Full-Text
Keywords: chitosan; agarose; magnetic nanoparticles; magnetic hyperthermia chitosan; agarose; magnetic nanoparticles; magnetic hyperthermia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zamora-Mora, V.; Soares, P.I.; Echeverria, C.; Hernández, R.; Mijangos, C. Composite Chitosan/Agarose Ferrogels for Potential Applications in Magnetic Hyperthermia. Gels 2015, 1, 69-80.

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