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J. Fungi 2017, 3(2), 27; doi:10.3390/jof3020027

MIC Distributions and Evaluation of Fungicidal Activity for Amphotericin B, Itraconazole, Voriconazole, Posaconazole and Caspofungin and 20 Species of Pathogenic Filamentous Fungi Determined Using the CLSI Broth Microdilution Method

Public Health England United Kingdom, Mycology Reference Laboratory, Myrtle Road, Bristol BS2 8EL, UK
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Author to whom correspondence should be addressed.
Academic Editors: Ana Alastruey-Izquierdo and Stéphane Ranque
Received: 2 May 2017 / Revised: 23 May 2017 / Accepted: 24 May 2017 / Published: 31 May 2017
(This article belongs to the Special Issue Antifungal Susceptibility Testing)
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Abstract

For filamentous fungi (moulds), species-specific interpretive breakpoints and epidemiological cut-off values (ECVs) have only been proposed for a limited number of fungal species–antifungal agent combinations, with the result that clinical breakpoints are lacking for most emerging mould pathogens. In the current study, we have compiled minimum inhibitory concentration (MIC) data for 4869 clinical mould isolates and present full MIC distributions for amphotericin B, itraconazole, voriconazole, posaconazole, and caspofungin with these isolates which comprise 20 species/genera. In addition, we present the results of an assessment of the fungicidal activity of these same five antifungal agents against a panel of 123 mould isolates comprising 16 of the same species. View Full-Text
Keywords: filamentous fungi; susceptibility testing; ECVs; amphotericin B; itraconazole; posaconazole; voriconazole; caspofungin; fungicidal; wild-type distributions filamentous fungi; susceptibility testing; ECVs; amphotericin B; itraconazole; posaconazole; voriconazole; caspofungin; fungicidal; wild-type distributions
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Borman, A.M.; Fraser, M.; Palmer, M.D.; Szekely, A.; Houldsworth, M.; Patterson, Z.; Johnson, E.M. MIC Distributions and Evaluation of Fungicidal Activity for Amphotericin B, Itraconazole, Voriconazole, Posaconazole and Caspofungin and 20 Species of Pathogenic Filamentous Fungi Determined Using the CLSI Broth Microdilution Method. J. Fungi 2017, 3, 27.

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