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J. Fungi 2017, 3(2), 20; doi:10.3390/jof3020020

An Assessment of In Vitro Antifungal Activities of Efinaconazole and Itraconazole against Common Non-Dermatophyte Fungi Causing Onychomycosis

1
Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai Tamilnadu 600116, India
2
Jhaveri Microbiology Centre, LV Prasad Eye Institute, Kallam Anji Reddy Campus, L V Prasad Marg, Banjara Hills, Hyderabad Telangana 500034, India
3
Department of Microbiology, Kempegowda Institute of Medical Sciences, Athibabbe Road, Banashankari Stage II, Banashankari, Bengaluru Karnataka 560070, India
4
Department of Dermatology, Venereology & Leprosy, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai Tamilnadu 600116, India
*
Author to whom correspondence should be addressed.
Academic Editors: Ana Alastruey-Izquierdo and Stéphane Ranque
Received: 25 February 2017 / Revised: 27 April 2017 / Accepted: 3 May 2017 / Published: 5 May 2017
(This article belongs to the Special Issue Antifungal Susceptibility Testing)
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Abstract

Onychomycosis is a fungal nail infection which is relatively common and difficult to treat. Treatment modalities include nail avulsion, surgical debridement and combination therapy with oral and topical antifungal drugs. In spite of a host of available drugs, clinical cure rates remain discouraging. Drug toxicities, prolonged regimens, lack of patient compliance, and high keratin affinity of drugs are all contributive factors. Efinaconazole is a novel topical triazole antifungal agent that has shown excellent in vitro activity against both dermatophyte and non-dermatophyte fungi causing onychomycosis. This study presents the in vitro susceptibility profiles of 44 common non-dermatophyte fungi against efinaconazole and itraconazole, another azole drug used in the treatment of onychomycosis. View Full-Text
Keywords: antifungal susceptibility testing; Fusarium; Aspergillus; CLSI; efinaconazole; itraconazole; onychomycosis antifungal susceptibility testing; Fusarium; Aspergillus; CLSI; efinaconazole; itraconazole; onychomycosis
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MDPI and ACS Style

Tupaki-Sreepurna, A.; Jishnu, B.T.; Thanneru, V.; Sharma, S.; Gopi, A.; Sundaram, M.; Jyoti Kindo, A. An Assessment of In Vitro Antifungal Activities of Efinaconazole and Itraconazole against Common Non-Dermatophyte Fungi Causing Onychomycosis. J. Fungi 2017, 3, 20.

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