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J. Cardiovasc. Dev. Dis. 2017, 4(3), 8; doi:10.3390/jcdd4030008

Multiple Species Comparison of Cardiac Troponin T and Dystrophin: Unravelling the DNA behind Dilated Cardiomyopathy

School of Life Sciences, Medical School, Queens Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, Leicestershire LE12 5RD, UK
Author to whom correspondence should be addressed.
Received: 21 June 2017 / Revised: 1 July 2017 / Accepted: 5 July 2017 / Published: 7 July 2017
(This article belongs to the Special Issue Genetics and Treatment of Dilated Cardiomyopathy)
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Animals have frequently been used as models for human disorders and mutations. Following advances in genetic testing and treatment options, and the decreasing cost of these technologies in the clinic, mutations in both companion and commercial animals are now being investigated. A recent review highlighted the genes associated with both human and non-human dilated cardiomyopathy. Cardiac troponin T and dystrophin were observed to be associated with both human and turkey (troponin T) and canine (dystrophin) dilated cardiomyopathies. This review gives an overview of the work carried out in cardiac troponin T and dystrophin to date in both human and animal dilated cardiomyopathy. View Full-Text
Keywords: dilated cardiomyopathy; troponin; dystrophin; mutation; species dilated cardiomyopathy; troponin; dystrophin; mutation; species

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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England, J.; Loughna, S.; Rutland, C.S. Multiple Species Comparison of Cardiac Troponin T and Dystrophin: Unravelling the DNA behind Dilated Cardiomyopathy. J. Cardiovasc. Dev. Dis. 2017, 4, 8.

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