The Popeye Domain Containing Genes and Their Function in Striated Muscle
AbstractThe Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here, we will review their role in striated muscle as deduced from work in cell and animal models and the recent analysis of patients carrying a missense mutation in POPDC1. Evidence suggests that POPDC proteins control membrane trafficking of interacting proteins. Furthermore, we will discuss the current catalogue of established protein-protein interactions. In recent years, the number of POPDC-interacting proteins has been rising and currently includes ion channels (TREK-1), sarcolemma-associated proteins serving functions in mechanical stability (dystrophin), compartmentalization (caveolin 3), scaffolding (ZO-1), trafficking (NDRG4, VAMP2/3) and repair (dysferlin) or acting as a guanine nucleotide exchange factor for Rho-family GTPases (GEFT). Recent evidence suggests that POPDC proteins might also control the cellular level of the nuclear proto-oncoprotein c-Myc. These data suggest that this family of cAMP-binding proteins probably serves multiple roles in striated muscle.
Share & Cite This Article
Schindler, R.F.R.; Scotton, C.; French, V.; Ferlini, A.; Brand, T. The Popeye Domain Containing Genes and Their Function in Striated Muscle. J. Cardiovasc. Dev. Dis. 2016, 3, 22.
Schindler RFR, Scotton C, French V, Ferlini A, Brand T. The Popeye Domain Containing Genes and Their Function in Striated Muscle. Journal of Cardiovascular Development and Disease. 2016; 3(2):22.Chicago/Turabian Style
Schindler, Roland F.R.; Scotton, Chiara; French, Vanessa; Ferlini, Alessandra; Brand, Thomas. 2016. "The Popeye Domain Containing Genes and Their Function in Striated Muscle." J. Cardiovasc. Dev. Dis. 3, no. 2: 22.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.