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J. Cardiovasc. Dev. Dis. 2016, 3(2), 21; doi:10.3390/jcdd3020021

A Matter of the Heart: The African Clawed Frog Xenopus as a Model for Studying Vertebrate Cardiogenesis and Congenital Heart Defects

Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany
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Academic Editors: Georg Vogler and Rolf Bodmer
Received: 18 February 2016 / Revised: 25 May 2016 / Accepted: 30 May 2016 / Published: 4 June 2016
(This article belongs to the Special Issue Non-mammalian Animal Models to Study Heart Development and Disease)
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Abstract

The African clawed frog, Xenopus, is a valuable non-mammalian model organism to investigate vertebrate heart development and to explore the underlying molecular mechanisms of human congenital heart defects (CHDs). In this review, we outline the similarities between Xenopus and mammalian cardiogenesis, and provide an overview of well-studied cardiac genes in Xenopus, which have been associated with congenital heart conditions. Additionally, we highlight advantages of modeling candidate genes derived from genome wide association studies (GWAS) in Xenopus and discuss commonly used techniques. View Full-Text
Keywords: Xenopus; heart development; congenital heart defects; morpholino; model organism Xenopus; heart development; congenital heart defects; morpholino; model organism
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Hempel, A.; Kühl, M. A Matter of the Heart: The African Clawed Frog Xenopus as a Model for Studying Vertebrate Cardiogenesis and Congenital Heart Defects. J. Cardiovasc. Dev. Dis. 2016, 3, 21.

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