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J. Cardiovasc. Dev. Dis. 2016, 3(2), 23; doi:10.3390/jcdd3020023

Vascular Development and Regeneration in the Mammalian Heart

1,2
,
3,4,5
and
1,2,*
1
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
2
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
3
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
4
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
5
School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
*
Author to whom correspondence should be addressed.
Academic Editors: Sean M. Wu and Neil C. Chi
Received: 27 April 2016 / Revised: 31 May 2016 / Accepted: 14 June 2016 / Published: 16 June 2016
(This article belongs to the Special Issue Myocardial Reprogramming in Development and Regeneration)
View Full-Text   |   Download PDF [201 KB, uploaded 16 June 2016]   |  

Abstract

Cardiovascular diseases including coronary artery disease are the leading cause of death worldwide. Unraveling the developmental origin of coronary vessels could offer important therapeutic implications for treatment of cardiovascular diseases. The recent identification of the endocardial source of coronary vessels reveals a heterogeneous origin of coronary arteries in the adult heart. In this review, we will highlight recent advances in finding the sources of coronary vessels in the mammalian heart from lineage-tracing models as well as differentiation studies using pluripotent stem cells. Moreover, we will also discuss how we induce neovascularization in the damaged heart through transient yet highly efficient expression of VEGF-modified mRNAs as a potentially therapeutic delivery platform. View Full-Text
Keywords: vascular development; vascular endothelial cells; angiocrine factors; heart regeneration vascular development; vascular endothelial cells; angiocrine factors; heart regeneration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Leung, O.M.; Zhou, B.; Lui, K.O. Vascular Development and Regeneration in the Mammalian Heart. J. Cardiovasc. Dev. Dis. 2016, 3, 23.

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