Postnatal Cardiac Autonomic Nervous Control in Pediatric Congenital Heart Disease
AbstractCongenital heart disease is the most common congenital defect. During childhood, survival is generally good but, in adulthood, late complications are not uncommon. Abnormal autonomic control in children with congenital heart disease may contribute considerably to the pathophysiology of these long term sequelae. This narrative review of 34 studies aims to summarize current knowledge on function of the autonomic nervous system in children with a congenital heart defect. Large scale studies that measure both branches of the nervous system for prolonged periods of time in well-defined patient cohorts in various phases of childhood and adolescence are currently lacking. Pending such studies, there is not yet a good grasp on the extent and direction of sympathetic and parasympathetic autonomic function in pediatric congenital heart disease. Longitudinal studies in homogenous patient groups linking autonomic nervous system function and clinical outcome are warranted. View Full-Text
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Nederend, I.; Jongbloed, M.R.M.; de Geus, E.J.C.; Blom, N.A.; ten Harkel, A.D.J. Postnatal Cardiac Autonomic Nervous Control in Pediatric Congenital Heart Disease. J. Cardiovasc. Dev. Dis. 2016, 3, 16.
Nederend I, Jongbloed MRM, de Geus EJC, Blom NA, ten Harkel ADJ. Postnatal Cardiac Autonomic Nervous Control in Pediatric Congenital Heart Disease. Journal of Cardiovascular Development and Disease. 2016; 3(2):16.Chicago/Turabian Style
Nederend, Ineke; Jongbloed, Monique R.M.; de Geus, Eco J.C.; Blom, Nico A.; ten Harkel, Arend D.J. 2016. "Postnatal Cardiac Autonomic Nervous Control in Pediatric Congenital Heart Disease." J. Cardiovasc. Dev. Dis. 3, no. 2: 16.
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