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J. Cardiovasc. Dev. Dis. 2016, 3(2), 15; doi:10.3390/jcdd3020015

On the Morphology of the Drosophila Heart

Department of Zoology/Developmental Biology, University of Osnabrück, Osnabrück 49069, Germany
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Author to whom correspondence should be addressed.
Academic Editors: Rolf Bodmer and Georg Vogler
Received: 25 January 2016 / Revised: 3 March 2016 / Accepted: 29 March 2016 / Published: 12 April 2016
(This article belongs to the Special Issue Non-mammalian Animal Models to Study Heart Development and Disease)
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Abstract

The circulatory system of Drosophila melanogaster represents an easily amenable genetic model whose analysis at different levels, i.e., from single molecules up to functional anatomy, has provided new insights into general aspects of cardiogenesis, heart physiology and cardiac aging, to name a few examples. In recent years, the Drosophila heart has also attracted the attention of researchers in the field of biomedicine. This development is mainly due to the fact that several genes causing human heart disease are also present in Drosophila, where they play the same or similar roles in heart development, maintenance or physiology as their respective counterparts in humans. This review will attempt to briefly introduce the anatomy of the Drosophila circulatory system and then focus on the different cell types and non-cellular tissue that constitute the heart. View Full-Text
Keywords: Drosophila melanogaster; cardiovascular system; heart; dorsal vessel; circulatory system Drosophila melanogaster; cardiovascular system; heart; dorsal vessel; circulatory system
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rotstein, B.; Paululat, A. On the Morphology of the Drosophila Heart. J. Cardiovasc. Dev. Dis. 2016, 3, 15.

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