Cellular Mechanisms of Drosophila Heart Morphogenesis
Abstract
:1. Introduction
2. Genetics of Drosophila Heart Formation
2.1. Genetic Control of Cardiac Specification
2.2. Genetics of Heart Morphogenesis
2.3. Analyzing the Actomyosin Network during Drosophila Heart Morphogenesis
3. Conclusions
Drosophila Gene | Class | Selected Ref. | Vertebrate Ortholog(s) | Selected Ref. |
---|---|---|---|---|
Diaphanous | Formin | [69] | DRF3 | [10] |
Zipper | Non-muscle myosin | [69] | NMHC-II A/B/C | [43,81] |
Netrin | Signaling molecule | [82,83] | NET1/3 | [84] |
Slit | Signaling molecule | [59,60,61,62,69,85] | SLIT1/2/3 | [64,86] |
Decapentaplegic | Signaling molecule | [87] | BMPs | [88] |
Wingless | Signaling molecule | [89] | WNTs | [90] |
Frazzled | Signaling Receptor | [83] | NEO1 | [91] |
heartless | Signaling Receptor | [92] | FGFR3/4 | [93] |
Notch | Signaling Receptor | [25] | NOTCH1/2/3 | [94] |
Robo1/2/3 | Signaling Receptor | [59,61,62,85] | ROBO1/2/3/4 | [64] |
Unc-5 | Signaling Receptor | [82] | UNC5A/B/C/D | [95] |
Kuzbanian | ADAM10 metalloprotease | [23] | ADAM10 | [96] |
Cdc42 | Small Rho GTPase | [69,70] | CDC42 | [68,97] |
Multiplexin | Collagen type XV/XVIII | [54] | COL15/18 | [98,99] |
dHand | Transcription factor | [33,100,101] | HAND1/2 | [102,103] |
DMef2 | Transcription factor | [32,104,105] | MEF2A/C/D | [106,107] |
Dorsocross1/2/3 | Transcription factor | [29] | TBX2/3/5 | [108,109,110] |
Ladybird-early/late | Transcription factor | [111,112] | Lbx1/2/3 | [113] |
Neuromancer1/2 | Transcription factor | [34,35,114] | TBX20 | [115,116] |
Pannier | Transcription factor | [30,117,118] | GATA4/6 | [119] |
Seven-up | Transcription factor | [38,45] | COUP-TF II | [120] |
Tail-up | Transcription factor | [36,37,121] | ISL1 | [122] |
Tinman | Transcription factor | [27,28] | NKX2.5 | [123] |
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Vogler, G.; Bodmer, R. Cellular Mechanisms of Drosophila Heart Morphogenesis. J. Cardiovasc. Dev. Dis. 2015, 2, 2-16. https://doi.org/10.3390/jcdd2010002
Vogler G, Bodmer R. Cellular Mechanisms of Drosophila Heart Morphogenesis. Journal of Cardiovascular Development and Disease. 2015; 2(1):2-16. https://doi.org/10.3390/jcdd2010002
Chicago/Turabian StyleVogler, Georg, and Rolf Bodmer. 2015. "Cellular Mechanisms of Drosophila Heart Morphogenesis" Journal of Cardiovascular Development and Disease 2, no. 1: 2-16. https://doi.org/10.3390/jcdd2010002