Next Article in Journal / Special Issue
The Popeye Domain Containing Genes and cAMP Signaling
Previous Article in Journal / Special Issue
Wnt/β-Catenin Signaling during Cardiac Development and Repair
Article Menu

Export Article

Open AccessReview
J. Cardiovasc. Dev. Dis. 2014, 1(1), 111-120; doi:10.3390/jcdd1010111

The Ig CAM CAR is Implicated in Cardiac Development and Modulates Electrical Conduction in the Mature Heart

Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13092 Berlin, Germany
Present address: Department of Neuroscience, Erasmus University Medical Center, P.O. Box 2040, NL-3000 CA, Rotterdam, The Netherlands.
*
Authors to whom correspondence should be addressed.
Received: 31 January 2014 / Revised: 30 April 2014 / Accepted: 6 May 2014 / Published: 21 May 2014
View Full-Text   |   Download PDF [936 KB, uploaded 21 May 2014]   |  

Abstract

The coxsackievirus and adenovirus receptor (CAR, CXADR) is a multi-functional cell adhesion molecule which forms with CLMP, BT-IgSF, ESAM and CTX a structural subgroup within the Ig superfamily. These proteins share an overall domain organization with two extracellular Ig domains, a transmembrane region and a cytoplasmic tail which includes a PDZ binding motif. CAR is strongly expressed in brain and heart during embryonic development and becomes down-regulated in early postnatal stages. Cell adhesion experiments, binding studies and as well as crystallographic investigations on the extracellular domain reveal a flexible ectodomain for CAR that mediates homophilic and heterophilic binding. Several animal models showed an essential role for CAR during embryonic heart development and for electrical conduction between neighboring cardiomyocytes at mature stages. CAR gets re-expressed in diseased or damaged cardiac tissue, probably to induce regeneration and remodeling of the cardiac muscle.
Keywords: CAR; cell adhesion; IgCAM; cardiac development; electrical conduction CAR; cell adhesion; IgCAM; cardiac development; electrical conduction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Matthäus, C.; Schreiber, J.; Jüttner, R.; Rathjen, F.G. The Ig CAM CAR is Implicated in Cardiac Development and Modulates Electrical Conduction in the Mature Heart. J. Cardiovasc. Dev. Dis. 2014, 1, 111-120.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top