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J. Cardiovasc. Dev. Dis. 2014, 1(1), 98-110; doi:10.3390/jcdd1010098
Review

Wnt/β-Catenin Signaling during Cardiac Development and Repair

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Received: 21 February 2014 / Revised: 28 April 2014 / Accepted: 30 April 2014 / Published: 21 May 2014
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Abstract

Active Wnt/β-catenin signaling is essential for proper cardiac specification, progenitor expansion and myocardial growth. During development, the mass of the embryonic heart increases multiple times to achieve the dimensions of adult ventricular chambers. Cell division in the embryonic heart is fairly present, whereas cell turnover in the adult myocardium is extremely low. Understanding of embryonic cardiomyocyte cell-replication, therefore, could improve strategies for cardiac regenerative therapeutics. Here, we review which role Wnt signaling plays in cardiac development and highlight a selection of attempts that have been made to modulate Wnt signaling after cardiac ischemic injury to improve cardiac function and reduce infarct size.
Keywords: Wnt/β-catenin; heart; development; cardiomyocyte proliferation; regenerative medicine Wnt/β-catenin; heart; development; cardiomyocyte proliferation; regenerative medicine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Buikema, J.W.; Zwetsloot, P.-P.M.; Doevendans, P.A.; Domian, I.J.; Sluijter, J.P.G. Wnt/β-Catenin Signaling during Cardiac Development and Repair. J. Cardiovasc. Dev. Dis. 2014, 1, 98-110.

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J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert