Next Article in Journal
Minimising Stress for Patients in the Veterinary Hospital: Why It Is Important and What Can Be Done about It
Previous Article in Journal
Coronary Artery Anomalies in Animals
Previous Article in Special Issue
Hyponatremia as the Presenting Feature of a Pituitary Abscess in a Calf
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview
Vet. Sci. 2017, 4(2), 21; doi:10.3390/vetsci4020021

Animal Models of Cancer-Associated Hypercalcemia

1
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
2
Department of Pathology, Faculty of Veterinary Medicine, Benha University, Banha 13511, Egypt
*
Author to whom correspondence should be addressed.
Academic Editor: Ir. J. A. Jan Mol
Received: 11 December 2016 / Revised: 14 March 2017 / Accepted: 10 April 2017 / Published: 13 April 2017
(This article belongs to the Special Issue Comparative studies on Endocrine Diseases in Animals and Humans)
View Full-Text   |   Download PDF [2284 KB, uploaded 13 April 2017]   |  

Abstract

Cancer-associated hypercalcemia (CAH) is a frequently-occurring paraneoplastic syndrome that contributes to substantial patient morbidity and occurs in both humans and animals. Patients with CAH are often characterized by markedly elevated serum calcium concentrations that result in a range of clinical symptoms involving the nervous, gastrointestinal and urinary systems. CAH is caused by two principle mechanisms; humorally-mediated and/or through local osteolytic bone metastasis resulting in excessive calcium release from resorbed bone. Humoral hypercalcemia of malignancy (HHM) is the most common mechanism and is due to the production and release of tumor-associated cytokines and humoral factors, such as parathyroid hormone-related protein (PTHrP), that act at distant sites to increase serum calcium concentrations. Local osteolytic hypercalcemia (LOH) occurs when primary or metastatic bone tumors act locally by releasing factors that stimulate osteoclast activity and bone resorption. LOH is a less frequent cause of CAH and in some cases can induce hypercalcemia in concert with HHM. Rarely, ectopic production of parathyroid hormone has been described. PTHrP-mediated hypercalcemia is the most common mechanism of CAH in human and canine malignancies and is recognized in other domestic species. Spontaneous and experimentally-induced animal models have been developed to study the mechanisms of CAH. These models have been essential for the evaluation of novel approaches and adjuvant therapies to manage CAH. This review will highlight the comparative aspects of CAH in humans and animals with a discussion of the available animal models used to study the pathogenesis of this important clinical syndrome. View Full-Text
Keywords: hypercalcemia; paraneoplastic syndrome; cat; comparative oncology; dog; HHM; PTHrP; bone metastasis hypercalcemia; paraneoplastic syndrome; cat; comparative oncology; dog; HHM; PTHrP; bone metastasis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kohart, N.A.; Elshafae, S.M.; Breitbach, J.T.; Rosol, T.J. Animal Models of Cancer-Associated Hypercalcemia. Vet. Sci. 2017, 4, 21.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Vet. Sci. EISSN 2306-7381 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top