Next Article in Journal
Hyponatremia as the Presenting Feature of a Pituitary Abscess in a Calf
Next Article in Special Issue
Micro-RNA 10a Is Increased in Feline T Regulatory Cells and Increases Foxp3 Protein Expression Following In Vitro Transfection
Previous Article in Journal
Review on Usage of Vancomycin in Livestock and Humans: Maintaining Its Efficacy, Prevention of Resistance and Alternative Therapy
Previous Article in Special Issue
The Use of Recombinant Feline Interferon Omega Therapy as an Immune-Modulator in Cats Naturally Infected with Feline Immunodeficiency Virus: New Perspectives
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessReview
Vet. Sci. 2017, 4(1), 7; doi:10.3390/vetsci4010007

The Comparative Value of Feline Virology Research: Can Findings from the Feline Lentiviral Vaccine Be Translated to Humans?

1
MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK
2
Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand
*
Authors to whom correspondence should be addressed.
Academic Editors: Rick Meeker and Jonathan Fogle
Received: 13 December 2016 / Revised: 17 January 2017 / Accepted: 24 January 2017 / Published: 28 January 2017
(This article belongs to the Special Issue Comparative Studies on HIV and FIV in Animals and Humans)
View Full-Text   |   Download PDF [855 KB, uploaded 3 February 2017]   |  

Abstract

Feline immunodeficiency virus (FIV) is a lentivirus of domestic cats that shares several similarities with its human counterpart, human immunodeficiency virus (HIV). Their analogies include genomic organization, lymphocyte tropism, viral persistence and induction of immunodeficiency. FIV is the only lentivirus for which a commercial vaccine is registered for prevention in either human or veterinary medicine. This provides a unique opportunity to investigate the mechanisms of protection induced by lentivirus vaccines at the population level and might contribute to the development of efficacious HIV vaccines. As well as having comparative value for vaccine studies, FIV research has shed some light on the relationship between lentiviral tropism and pathogenesis. Recent studies in our laboratory demonstrated that the interaction between FIV and its primary receptor changes as disease progresses, reminiscent of the receptor switch observed as disease progresses in HIV infected individuals. Here we summarise findings illustrating that, in addition to its veterinary significance, FIV has comparative value, providing a useful model to explore lentivirus–host interactions and to examine potential immune correlates of protection against HIV infection. View Full-Text
Keywords: feline immunodeficiency virus; human immunodeficiency virus; vaccine; tropism; comparative study feline immunodeficiency virus; human immunodeficiency virus; vaccine; tropism; comparative study
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hosie, M.J.; Techakriengkrai, N.; Bęczkowski, P.M.; Harris, M.; Logan, N.; Willett, B.J. The Comparative Value of Feline Virology Research: Can Findings from the Feline Lentiviral Vaccine Be Translated to Humans? Vet. Sci. 2017, 4, 7.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Vet. Sci. EISSN 2306-7381 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top