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Vet. Sci. 2017, 4(1), 19; doi:10.3390/vetsci4010019

Genomic Insights into Cardiomyopathies: A Comparative Cross-Species Review

1
Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
2
Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Sonja Fonfara and Lynne O’Sullivan
Received: 27 December 2016 / Revised: 15 March 2017 / Accepted: 15 March 2017 / Published: 21 March 2017
(This article belongs to the Special Issue Comparison of Cardiovascular Systems and Diseases Across Species)
View Full-Text   |   Download PDF [294 KB, uploaded 21 March 2017]

Abstract

In the global human population, the leading cause of non-communicable death is cardiovascular disease. It is predicted that by 2030, deaths attributable to cardiovascular disease will have risen to over 20 million per year. This review compares the cardiomyopathies in both human and non-human animals and identifies the genetic associations for each disorder in each species/taxonomic group. Despite differences between species, advances in human medicine can be gained by utilising animal models of cardiac disease; likewise, gains can be made in animal medicine from human genomic insights. Advances could include undertaking regular clinical checks in individuals susceptible to cardiomyopathy, genetic testing prior to breeding, and careful administration of breeding programmes (in non-human animals), further development of treatment regimes, and drugs and diagnostic techniques. View Full-Text
Keywords: cardiomyopathy; human; canine; cross-species; cardiovascular disease; genetics cardiomyopathy; human; canine; cross-species; cardiovascular disease; genetics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Simpson, S.; Rutland, P.; Rutland, C.S. Genomic Insights into Cardiomyopathies: A Comparative Cross-Species Review. Vet. Sci. 2017, 4, 19.

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