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Vet. Sci. 2017, 4(1), 14; doi:10.3390/vetsci4010014

Feline Immunodeficiency Virus Neuropathogenesis: A Model for HIV-Induced CNS Inflammation and Neurodegeneration

1
Department of Neurology, University of North Carolina, Chapel Hill, NC 27599, USA
2
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick Butaye
Received: 12 January 2017 / Revised: 22 February 2017 / Accepted: 1 March 2017 / Published: 6 March 2017
(This article belongs to the Special Issue Comparative Studies on HIV and FIV in Animals and Humans)
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Abstract

Feline Immunodeficiency virus (FIV), similar to its human analog human immunodeficiency virus (HIV), enters the central nervous system (CNS) soon after infection and establishes a protected viral reservoir. The ensuing inflammation and damage give rise to varying degrees of cognitive decline collectively known as HIV-associated neurocognitive disorders (HAND). Because of the similarities to HIV infection and disease, FIV has provided a useful model for both in vitro and in vivo studies of CNS infection, inflammation and pathology. This mini review summarizes insights gained from studies of early infection, immune cell trafficking, inflammation and the mechanisms of neuropathogenesis. Advances in our understanding of these processes have contributed to the development of therapeutic interventions designed to protect neurons and regulate inflammatory activity. View Full-Text
Keywords: AIDS; human immunodeficiency virus; dementia; neurons; microglia; macrophages AIDS; human immunodeficiency virus; dementia; neurons; microglia; macrophages
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Meeker, R.B.; Hudson, L. Feline Immunodeficiency Virus Neuropathogenesis: A Model for HIV-Induced CNS Inflammation and Neurodegeneration. Vet. Sci. 2017, 4, 14.

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