Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs
AbstractNovel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry. The engineered bioink was loaded with Ropinirole HCL, dispensed through a piezoelectric nozzle onto a blank preform tablet, and polymerized. Drug release analysis of the tablet resulted in 60% release within 15 min of tablet dissolution. The study confirms the potential of inkjet printing for the rapid production of tablets through the deposition of a photocurable bioink designed for hydrophilic APIs. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 335 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Acosta-Vélez, G.F.; Linsley, C.S.; Craig, M.C.; Wu, B.M. Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs. Bioengineering 2017, 4, 11.
Acosta-Vélez GF, Linsley CS, Craig MC, Wu BM. Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs. Bioengineering. 2017; 4(1):11.Chicago/Turabian Style
Acosta-Vélez, Giovanny F.; Linsley, Chase S.; Craig, Madison C.; Wu, Benjamin M. 2017. "Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs." Bioengineering 4, no. 1: 11.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.