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Bioengineering 2017, 4(1), 11; doi:10.3390/bioengineering4010011

Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs

1
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5531, Boelter Hall, P.O. Box: 951592, Los Angeles, CA 90095-1592, USA
2
Department of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5121, Engineering V, P.O. Box: 951600, Los Angeles, CA 90095, USA
3
Division of Advanced Prosthodontics and the Weintraub Center for Reconstructive Biotechnology, University of California, Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jacqueline J. Alblas
Received: 21 December 2016 / Revised: 13 January 2017 / Accepted: 24 January 2017 / Published: 28 January 2017
(This article belongs to the Special Issue Advances in 3D Printing of Biomaterials)
View Full-Text   |   Download PDF [2001 KB, uploaded 10 February 2017]   |  

Abstract

Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry. The engineered bioink was loaded with Ropinirole HCL, dispensed through a piezoelectric nozzle onto a blank preform tablet, and polymerized. Drug release analysis of the tablet resulted in 60% release within 15 min of tablet dissolution. The study confirms the potential of inkjet printing for the rapid production of tablets through the deposition of a photocurable bioink designed for hydrophilic APIs. View Full-Text
Keywords: 3D printing; pharmaceutical tablets; hyaluronic acid; inkjet printing; Ropinirole; norbornene 3D printing; pharmaceutical tablets; hyaluronic acid; inkjet printing; Ropinirole; norbornene
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Acosta-Vélez, G.F.; Linsley, C.S.; Craig, M.C.; Wu, B.M. Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs. Bioengineering 2017, 4, 11.

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