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Bioengineering 2017, 4(1), 10; doi:10.3390/bioengineering4010010

3D Printing of Organs-On-Chips

Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk 37673, Korea
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Hyun Jung Kim
Received: 29 November 2016 / Revised: 14 January 2017 / Accepted: 20 January 2017 / Published: 25 January 2017
(This article belongs to the Special Issue Human Organs-on-Chips for In Vitro Disease Models)
View Full-Text   |   Download PDF [2452 KB, uploaded 25 January 2017]   |  

Abstract

Organ-on-a-chip engineering aims to create artificial living organs that mimic the complex and physiological responses of real organs, in order to test drugs by precisely manipulating the cells and their microenvironments. To achieve this, the artificial organs should to be microfabricated with an extracellular matrix (ECM) and various types of cells, and should recapitulate morphogenesis, cell differentiation, and functions according to the native organ. A promising strategy is 3D printing, which precisely controls the spatial distribution and layer-by-layer assembly of cells, ECMs, and other biomaterials. Owing to this unique advantage, integration of 3D printing into organ-on-a-chip engineering can facilitate the creation of micro-organs with heterogeneity, a desired 3D cellular arrangement, tissue-specific functions, or even cyclic movement within a microfluidic device. Moreover, fully 3D-printed organs-on-chips more easily incorporate other mechanical and electrical components with the chips, and can be commercialized via automated massive production. Herein, we discuss the recent advances and the potential of 3D cell-printing technology in engineering organs-on-chips, and provides the future perspectives of this technology to establish the highly reliable and useful drug-screening platforms. View Full-Text
Keywords: 3D printing; cell-printing; bioprinting; organ-on-a-chip; in vitro tissue model; in vitro disease model 3D printing; cell-printing; bioprinting; organ-on-a-chip; in vitro tissue model; in vitro disease model
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yi, H.-G.; Lee, H.; Cho, D.-W. 3D Printing of Organs-On-Chips. Bioengineering 2017, 4, 10.

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